Biomechanics and Modeling in Mechanobiology
Scope & Guideline
Pioneering Research at the Crossroads of Mechanics and Biology
Introduction
Aims and Scopes
- Computational Modeling of Biological Systems:
The journal extensively publishes research on computational models that simulate biological processes, including growth, remodeling, and physiological responses under mechanical loading. - Mechanobiology and its Applications:
Research focusing on how mechanical forces influence biological systems, focusing on cellular behavior, tissue development, and disease mechanisms. - Interdisciplinary Approaches:
The journal encourages interdisciplinary studies that integrate principles from engineering, biology, and medical sciences to address complex biological problems. - Innovative Simulation Techniques:
Emphasis on novel simulation techniques, including finite element analysis, fluid-structure interaction, and machine learning approaches to model biological phenomena. - Patient-Specific Modeling:
A strong focus on individual variability and personalized medicine, where models are tailored to specific patient anatomies and conditions to enhance treatment outcomes. - Multiscale Modeling:
Research that spans multiple scales, from molecular to organ systems, capturing the interactions between different biological levels and their mechanical responses.
Trending and Emerging
- Integration of Machine Learning:
An increasing number of studies are incorporating machine learning techniques to analyze complex biomechanical data and optimize modeling processes, enhancing predictive capabilities. - Personalized Medicine and Patient-Specific Models:
There is a growing trend towards developing patient-specific computational models that account for individual anatomical and physiological variations, particularly in cardiovascular and orthopedic applications. - Mechanobiological Mechanisms in Disease:
Research focusing on the mechanobiological underpinnings of diseases, particularly in areas like cancer, cardiovascular diseases, and tissue degeneration, is gaining traction. - Fluid-Structure Interaction Models:
Emerging interest in fluid-structure interaction models that simulate complex interactions between biological fluids and structures, particularly in cardiovascular and pulmonary systems. - Multiscale and Multiphysics Modeling:
A trend towards comprehensive multiscale and multiphysics modeling approaches that capture the interactions and behaviors across different biological scales and physical phenomena. - Novel Biomaterials and Scaffolds:
Research on innovative biomaterials and scaffolds designed to respond to mechanical stimuli is becoming increasingly relevant, particularly for tissue engineering applications.
Declining or Waning
- Basic Biomechanical Studies:
There has been a noticeable decline in studies focused solely on fundamental biomechanical properties without integrating mechanobiological aspects or advanced modeling techniques. - Traditional Experimental Methods:
Research relying heavily on traditional experimental approaches without computational or modeling components is becoming less frequent as computational methods gain prominence. - Isolated Tissue Studies:
Papers focusing exclusively on isolated tissue mechanics without considering the broader physiological context or interactions within living systems are decreasing. - Static Modeling Approaches:
Static or one-dimensional models that do not account for dynamic interactions or multi-physics phenomena are seeing less interest in favor of more comprehensive, dynamic modeling. - Conventional Tissue Engineering Techniques:
There is a waning interest in conventional tissue engineering methods that do not incorporate mechanobiological principles, as the field moves towards more integrated approaches.
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