Journal of Cystic Fibrosis
Scope & Guideline
Advancing knowledge in cystic fibrosis management.
Introduction
Aims and Scopes
- CFTR Modulator Therapy:
A significant focus on the effectiveness and safety of CFTR modulators, including elexacaftor, tezacaftor, and ivacaftor, in treating various CF genotypes. - Microbiome Research:
Exploration of the cystic fibrosis microbiome, including its interactions with disease pathology and treatment responses, particularly regarding Pseudomonas aeruginosa and other pathogens. - Quality of Life and Patient-Centered Care:
Assessment of health-related quality of life and the psychosocial impact of cystic fibrosis on patients and their families, emphasizing the importance of holistic care. - Nutritional Management:
Research on dietary interventions, nutritional status, and gastrointestinal complications in cystic fibrosis, recognizing the critical role of nutrition in disease management. - Longitudinal Studies and Registries:
Utilization of registry data and longitudinal studies to understand disease progression, treatment outcomes, and long-term health implications for cystic fibrosis patients. - Clinical Guidelines and Standards of Care:
Development and dissemination of evidence-based clinical guidelines to improve standard care practices for cystic fibrosis patients across different demographics.
Trending and Emerging
- Telehealth and Digital Health Innovations:
An increasing number of studies are focusing on telehealth implementations and digital health tools to improve care delivery and patient engagement, especially in light of the COVID-19 pandemic. - Pharmacogenomics and Personalized Medicine:
Research into pharmacogenomic approaches is gaining traction, aiming to tailor CF treatments based on individual genetic profiles, thereby enhancing therapeutic efficacy. - Impact of Socioeconomic Factors:
Emerging themes are addressing the influence of socioeconomic factors on health outcomes in cystic fibrosis, emphasizing the need for equitable access to care and treatment. - Mental Health and Psychosocial Research:
There is a growing emphasis on mental health outcomes and the psychosocial impact of living with cystic fibrosis, highlighting the importance of addressing emotional well-being in treatment plans. - Longitudinal Outcomes of Novel Therapies:
Studies focusing on the long-term effectiveness and safety of recently approved therapies, particularly CFTR modulators, are becoming increasingly prevalent.
Declining or Waning
- Basic Science Research:
There has been a noticeable decrease in basic science studies focused solely on the pathology of cystic fibrosis, as the field shifts towards applied research and clinical trials. - Traditional Antibiotic Therapies:
Interest in conventional antibiotic therapies appears to be waning, likely due to the rise of new CFTR modulators and alternative treatment strategies that target the underlying cause of the disease. - Palliative Care Research:
Although still important, there seems to be less emphasis on palliative care studies compared to previous years, possibly overshadowed by advancements in curative and disease-modifying therapies. - Longitudinal Studies of Older Treatment Regimens:
Research focusing on the long-term efficacy of older treatment regimens, such as dornase alfa, is becoming less frequent as newer therapies dominate clinical discussions.
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