MAMMALIAN GENOME
Scope & Guideline
Advancing the frontiers of mammalian genetics.
Introduction
Aims and Scopes
- Mammalian Genetics and Genomics:
The journal covers a wide range of topics related to the genetics of various mammalian species, including the identification of genetic variants, genomic mapping, and the role of specific genes in health and disease. - Model Organisms and Disease Models:
A significant focus is placed on the use of mouse models and other mammalian species to explore disease mechanisms, develop therapeutic strategies, and understand genetic disorders. - Comparative Genomics:
Research that compares genomes across different mammalian species to uncover evolutionary relationships and functional conservation is a key area of interest. - Functional Genomics and Phenotyping:
The journal includes studies on high-throughput phenotyping, transcriptomic analyses, and the functional characterization of genes and non-coding RNAs. - Resource Development:
Mammalian Genome serves as a hub for the development and sharing of genomic resources, including databases, biobanks, and repositories for mutant and genetically altered mouse models.
Trending and Emerging
- Network Medicine Approaches:
There is an increasing interest in network medicine, which integrates genomic data with other biological and clinical information to identify disease mechanisms and potential therapeutic targets. - Epigenetics and Non-Coding RNAs:
Research on epigenetic modifications and the role of non-coding RNAs in gene regulation and disease is gaining traction, indicating a shift towards understanding complex regulatory networks. - Systems Biology and Integrative Genomics:
Emerging themes include systems biology approaches that combine genomic, transcriptomic, and phenotypic data to provide comprehensive insights into mammalian biology. - High-Throughput Genomic Technologies:
The utilization of advanced genomic technologies such as CRISPR, whole-genome sequencing, and high-throughput phenotyping is on the rise, facilitating deeper exploration of genetic functions and interactions. - Comparative and Evolutionary Genomics:
There is a growing trend towards comparative genomics that seeks to understand evolutionary relationships and functional conservation across species, particularly in relation to disease susceptibility.
Declining or Waning
- Microbiome Studies:
Research specifically focused on the gut microbiome in relation to mammalian health and disease appears to have diminished, possibly as the field has matured or integrated into broader studies of mammalian biology. - Basic Gene Expression Studies:
There is a noticeable decline in papers focusing solely on basic gene expression without the context of functional or disease-related studies, indicating a shift towards more applied genetic research. - Traditional Phenotyping Methods:
Papers that rely on traditional, lower-throughput phenotyping techniques seem to be less frequent, as the field moves towards high-throughput and integrated approaches. - Single Species Studies:
Research focusing exclusively on a single mammalian species, particularly those that do not contribute to translational insights or comparative analysis, has been less common, reflecting a trend towards more comparative and integrative studies.
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