Skeletal Muscle
Scope & Guideline
Pioneering research that shapes the landscape of muscle science.
Introduction
Aims and Scopes
- Muscle Biology and Physiology:
Research on the cellular and molecular mechanisms underlying muscle formation, maintenance, and function, including studies on myogenesis, muscle fiber types, and the role of various signaling pathways. - Muscle Pathology and Disease Mechanisms:
Exploration of the cellular and genetic factors contributing to muscle diseases such as muscular dystrophies, sarcopenia, and cachexia, with a focus on understanding the mechanisms of muscle degeneration and regeneration. - Therapeutic Strategies in Muscle Disorders:
Investigations into novel therapeutic approaches, including gene therapy, pharmacological interventions, and regenerative medicine techniques aimed at treating muscle-related conditions. - Muscle Regeneration and Repair:
Studies on the processes of muscle regeneration following injury or atrophy, including the roles of satellite cells, growth factors, and extracellular matrix components. - Impact of Aging and Metabolism on Muscle Health:
Research examining the effects of aging, metabolic disorders, and lifestyle factors (such as exercise) on skeletal muscle function and health.
Trending and Emerging
- Gene Therapy and Genetic Interventions:
There is a notable increase in research focused on gene therapy techniques, such as AAV gene delivery systems, targeting genetic muscle diseases, and exploring their therapeutic potential. - Muscle Aging and Sarcopenia:
Studies on the mechanisms of muscle aging and sarcopenia are gaining traction, highlighting the importance of understanding age-related muscle loss and its implications for health in older populations. - Multi-Omics Approaches:
The adoption of multi-omics methodologies to investigate muscle biology and disease is on the rise, providing comprehensive insights into the complex interactions of genes, proteins, and metabolites in muscle health. - Impact of the Microenvironment on Muscle Regeneration:
Emerging research is focusing on the role of the muscle microenvironment, including cellular interactions and extracellular matrix components, in influencing muscle regeneration and repair processes. - Inflammation and Immune Response in Muscle Disease:
There is an increasing emphasis on the role of inflammation and immune responses in muscle degeneration and regeneration, particularly in the context of chronic diseases and aging.
Declining or Waning
- General Muscle Physiology without Disease Context:
There seems to be a decline in studies focusing solely on basic muscle physiology without a clear link to disease mechanisms or therapeutic implications, suggesting a shift towards more clinically relevant research. - Non-Specific Animal Model Studies:
Research utilizing generic animal models without a specific disease context has decreased, indicating a trend towards more targeted studies that address particular muscle disorders or conditions. - Historical Reviews and Case Reports:
The frequency of publications centered on historical reviews or isolated case reports appears to be waning, as the journal increasingly favors original research that contributes novel insights into muscle biology and disease.
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