ACS Chemical Biology

Scope & Guideline

Driving Innovation in Biochemistry and Molecular Medicine

Introduction

Welcome to the ACS Chemical Biology information hub, where our guidelines provide a wealth of knowledge about the journal’s focus and academic contributions. This page includes an extensive look at the aims and scope of ACS Chemical Biology, highlighting trending and emerging areas of study. We also examine declining topics to offer insight into academic interest shifts. Our curated list of highly cited topics and recent publications is part of our effort to guide scholars, using these guidelines to stay ahead in their research endeavors.
LanguageEnglish
ISSN1554-8929
PublisherAMER CHEMICAL SOC
Support Open AccessNo
CountryUnited States
TypeJournal
Convergefrom 2006 to 2024
AbbreviationACS CHEM BIOL / ACS Chem. Biol.
Frequency12 issues/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
Address1155 16TH ST, NW, WASHINGTON, DC 20036

Aims and Scopes

ACS Chemical Biology focuses on the intersection of chemistry and biology, emphasizing the development and application of chemical tools to investigate biological systems and processes. The journal serves as a platform for publishing innovative research that enhances our understanding of biological mechanisms through chemical approaches.
  1. Chemical Biology Techniques and Methodologies:
    The journal emphasizes the development and application of innovative chemical techniques for studying biological systems, including but not limited to, chemical probes, small-molecule inhibitors, and bioconjugation strategies.
  2. Protein Engineering and Design:
    A significant focus is placed on the engineering of proteins and peptides for various applications, including therapeutic development, biosensing, and understanding protein interactions.
  3. Natural Product Chemistry:
    The journal showcases research on the discovery, characterization, and biosynthesis of natural products, often highlighting their medicinal properties and potential therapeutic applications.
  4. Systems Biology and Metabolomics:
    Research in this area explores the interactions within biological systems using a chemical approach, providing insights into metabolic pathways and cellular responses.
  5. Targeted Protein Degradation and PROTACs:
    There is a growing emphasis on the development and application of proteolysis-targeting chimeras (PROTACs) and other strategies for targeted protein degradation, which are seen as promising therapeutic strategies.
  6. Chemical Genetics and Chemical Proteomics:
    The journal covers advancements in chemical genetics and proteomics that allow for the systematic study of gene function and protein interactions in living systems.
ACS Chemical Biology has been at the forefront of several emerging themes that reflect the evolving landscape of chemical biology. The following areas have gained significant momentum and are shaping the future direction of research in this field.
  1. Chemical Probes for Target Identification:
    There is a growing interest in the development of chemical probes that facilitate the identification of protein targets and elucidate mechanisms of action in complex biological systems.
  2. Bioconjugation and Chemical Tagging:
    The use of bioconjugation techniques to label and track biomolecules in vivo has seen a surge in research, highlighting its importance in studying cellular processes and therapeutic applications.
  3. RNA Modifications and Their Biological Roles:
    Research focusing on the chemical biology of RNA modifications, including m6A and other modifications, is rapidly emerging, reflecting the growing recognition of RNA's role in cellular regulation.
  4. Targeted Protein Degradation Technologies:
    The rise of PROTACs and other targeted protein degradation strategies is a key trend, with increasing publications exploring their potential in therapeutic applications.
  5. Synthetic Biology and Engineered Biological Systems:
    There is an increasing emphasis on synthetic biology approaches, including the design of engineered biological systems and pathways for therapeutic and industrial applications.
  6. Structural Biology and Drug Design Integration:
    The integration of structural biology techniques with drug design and chemical biology is gaining traction, leading to improved understanding of drug-target interactions and the development of more effective therapeutics.

Declining or Waning

While ACS Chemical Biology continues to thrive in many research areas, certain themes have shown signs of declining prominence over recent years. These waning scopes may reflect shifts in research focus or the maturation of specific fields within chemical biology.
  1. Traditional Small-Molecule Drug Discovery:
    There has been a noticeable decrease in publications focusing solely on traditional small-molecule drug discovery, as the field shifts towards more innovative approaches such as targeted protein degradation and bioconjugation.
  2. Basic Biochemical Pathway Studies:
    Research that primarily focuses on elucidating basic biochemical pathways without a clear application or integration with chemical biology tools appears to be less common.
  3. Single-Target Inhibitors:
    The trend has shifted from developing single-target inhibitors towards multi-target strategies and the use of PROTACs, indicating a waning interest in traditional single-target approaches.
  4. In Vivo Studies with Limited Biological Relevance:
    Studies that do not bridge the gap between in vitro findings and significant biological implications in vivo are becoming less frequent, as the emphasis shifts towards more translational research.

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