BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Scope & Guideline
Unveiling the Secrets of Proteins and Their Interactions
Introduction
Aims and Scopes
- Protein Structure and Function:
Research in this area involves elucidating the three-dimensional structures of proteins and understanding how these structures relate to their biological functions. This includes studies on conformational changes, dynamics, and interactions with other biomolecules. - Proteomics and Mass Spectrometry:
The journal publishes articles on proteomic techniques, particularly those utilizing mass spectrometry for the analysis of protein expression, post-translational modifications, and interactions. This area emphasizes the development and refinement of proteomic methodologies. - Biophysical Characterization of Proteins:
This scope encompasses the use of biophysical techniques, such as NMR, circular dichroism, and fluorescence spectroscopy, to study the physical properties of proteins, including stability, folding kinetics, and interactions. - Molecular Mechanisms in Health and Disease:
Research exploring the roles of proteins in various biological processes and diseases, including neurodegenerative conditions, cancer, and infectious diseases, is a central focus, emphasizing the molecular basis of pathology. - Chemical Biology and Drug Development:
This area covers studies that investigate the interactions of proteins with small molecules, including drug discovery and the development of therapeutic agents targeting specific protein functions.
Trending and Emerging
- Liquid-Liquid Phase Separation:
An increasing number of studies are focusing on the role of liquid-liquid phase separation in cellular organization and protein aggregation, particularly in neurodegenerative diseases. This theme highlights the importance of understanding how proteins behave in crowded cellular environments. - Machine Learning and AI in Proteomics:
The application of machine learning techniques to predict protein interactions, folding, and stability is gaining momentum. This trend signifies a shift towards computational approaches that can complement experimental methods, enhancing the predictive power of proteomic studies. - Post-Translational Modifications (PTMs):
Research exploring the functional implications of PTMs is increasingly prevalent, reflecting their critical roles in regulating protein function and interactions. This emerging focus underscores the complexity of protein regulation in various biological contexts. - Protein-Protein Interactions and Networks:
There is a growing emphasis on studying protein-protein interactions and their implications in biological systems, including signal transduction and disease mechanisms. This trend highlights the importance of understanding proteins in the context of larger biological networks. - Therapeutic Target Identification:
The journal is seeing more studies aimed at identifying novel therapeutic targets through proteomic and structural analyses, particularly in the context of cancer and infectious diseases. This reflects an increasing interest in translating protein research into clinical applications.
Declining or Waning
- Traditional Enzymology:
While enzymology remains a core area, there has been a noticeable decline in studies focusing solely on classical enzyme kinetics without integration into broader biological contexts or proteomic approaches. The shift towards systems biology and integrative methods may be overshadowing traditional enzyme studies. - Basic Protein Expression Studies:
Research focused exclusively on the expression levels of proteins in isolated systems, without context to cellular or organismal function, has decreased. The emphasis has shifted towards more complex analyses that integrate protein expression with functional outcomes. - Single-Protein Studies:
The trend is moving away from isolated studies of single proteins towards more comprehensive analyses involving protein networks and interactions. This reflects a growing understanding of the complexity of biological systems and the need for holistic approaches.
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