Acta Crystallographica Section D-Structural Biology
Scope & Guideline
Exploring the Intersection of Crystallography and Biology
Introduction
Aims and Scopes
- Macromolecular Crystallography:
The journal publishes research on the determination of three-dimensional structures of biological macromolecules using X-ray crystallography, including advances in crystallization techniques, data collection, and structure refinement. - Cryo-Electron Microscopy (Cryo-EM):
Research on cryo-EM is a significant focus, covering methods for sample preparation, data acquisition, and reconstruction of structures at near-atomic resolution. - Computational Methods in Structural Biology:
The journal highlights the use of computational approaches, including molecular modeling, machine learning, and deep learning, to predict structures and analyze macromolecular interactions. - Structural Dynamics and Kinetics:
Studies examining the dynamic aspects of biomolecules and their functional implications through time-resolved structural analysis are prominently featured. - Structural Insights into Biological Functions:
Papers often explore the relationship between structure and function, providing insights into biochemical pathways, enzyme mechanisms, and protein interactions. - Innovative Data Processing and Validation Techniques:
The journal emphasizes advancements in data processing, validation methods, and software tools that enhance the reliability of structural data.
Trending and Emerging
- Integration of AI and Machine Learning:
There is an increasing trend in utilizing artificial intelligence and machine learning techniques for data analysis, model validation, and structure prediction, showcasing the journal's adaptation to contemporary computational advancements. - Time-Resolved Structural Analysis:
Emerging research emphasizes time-resolved methods to study dynamic processes in biomolecules, allowing for insights into enzymatic mechanisms and conformational changes during function. - Fragment-Based Drug Design:
The journal has seen a rise in studies focusing on fragment-based approaches for drug discovery, highlighting structural insights that can lead to the development of novel therapeutics. - Structural Biology in Drug Development:
There is a growing emphasis on the role of structural biology in understanding drug interactions and mechanisms, particularly in the context of infectious diseases and cancer. - High-Throughput Screening and Automation:
Recent publications indicate a trend towards high-throughput methods and automation in crystallography and cryo-EM, facilitating rapid data collection and analysis. - Interdisciplinary Approaches:
The integration of structural biology with other disciplines such as bioinformatics, biochemistry, and systems biology is increasingly reflected in the journal's content, promoting a more holistic understanding of biological systems.
Declining or Waning
- Traditional X-ray Crystallography Techniques:
There is a noticeable decline in publications solely focused on traditional X-ray crystallography methods without incorporation of novel techniques or computational advancements. - Studies on Static Structures:
Research focused purely on static structures without dynamic or functional analysis has decreased, as there is a growing emphasis on understanding how structures relate to biological function. - Nuclear Magnetic Resonance (NMR) Studies:
Papers utilizing NMR spectroscopy for structural determination have become less frequent, possibly due to the rise of more accessible and high-resolution techniques like cryo-EM and advanced X-ray methods. - Focus on Non-Biological Macromolecules:
There has been a waning interest in the structural studies of non-biological macromolecules or materials, with a stronger emphasis now on biologically relevant targets.
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