BIOPHYSICAL JOURNAL

Scope & Guideline

Unveiling the complexities of biological phenomena.

Introduction

Explore the comprehensive scope of BIOPHYSICAL JOURNAL through our detailed guidelines, including its aims and scope. Stay updated with trending and emerging topics, and delve into declining areas to understand shifts in academic interest. Our guidelines also showcase highly cited topics, featuring influential research making a significant impact. Additionally, discover the latest published papers and those with high citation counts, offering a snapshot of current scholarly conversations. Use these guidelines to explore BIOPHYSICAL JOURNAL in depth and align your research initiatives with current academic trends.
LanguageEnglish
ISSN0006-3495
PublisherCELL PRESS
Support Open AccessNo
CountryUnited States
TypeJournal
Convergefrom 1960 to 2024
AbbreviationBIOPHYS J / Biophys. J.
Frequency24 issues/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
Address50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139

Aims and Scopes

The Biophysical Journal focuses on the interdisciplinary study of the physical principles underlying biological processes, aiming to elucidate the mechanisms of molecular interactions, cellular dynamics, and the intricate relationships between structure and function in biological systems.
  1. Molecular Dynamics Simulations:
    Utilizes advanced computational techniques to model the behavior and interactions of biomolecules, providing insights into their dynamics and structural changes.
  2. Single-Molecule Techniques:
    Employs methods such as single-molecule FRET and optical tweezers to investigate the interactions and conformational changes of proteins and nucleic acids at unprecedented resolution.
  3. Biophysical Characterization of Membranes:
    Explores the physical properties of lipid bilayers and membrane proteins, contributing to the understanding of membrane dynamics, transport mechanisms, and signal transduction.
  4. Structural Biology:
    Focuses on elucidating the three-dimensional structures of proteins, nucleic acids, and complexes using techniques like cryo-EM and X-ray crystallography to understand their functional roles.
  5. Mechanobiology:
    Investigates how mechanical forces influence cellular behavior, including migration, differentiation, and mechanotransduction, bridging the gap between physical stimuli and biological responses.
  6. Phase Separation in Biology:
    Studies the formation and dynamics of biomolecular condensates, exploring their roles in cellular organization, signaling, and disease processes.
  7. Drug Discovery and Development:
    Integrates biophysical techniques to assess ligand-receptor interactions, understand drug mechanisms, and develop therapeutics targeting various biological pathways.
The Biophysical Journal is witnessing a surge in interest around several emerging themes that reflect the evolving landscape of biophysical research, particularly in the context of new technologies and interdisciplinary approaches.
  1. Artificial Intelligence and Machine Learning:
    The integration of AI and machine learning techniques in biophysical research is on the rise, aiding in data analysis, predictive modeling, and the design of novel biomolecular interactions.
  2. Biomolecular Condensates and Phase Separation:
    Research into the role of biomolecular condensates in cellular organization and function is rapidly expanding, particularly in understanding their implications in diseases such as cancer and neurodegeneration.
  3. Advanced Imaging Techniques:
    There is an increasing focus on developing and applying high-resolution imaging methods, such as super-resolution microscopy and cryo-electron tomography, to study complex biological systems in real-time.
  4. Mechanobiology and Cellular Mechanics:
    Emerging studies are exploring how mechanical forces influence cellular behavior, linking physical properties to biological functions and highlighting the relevance of mechanotransduction pathways.
  5. Synthetic Biology and Protein Engineering:
    The trend towards designing and engineering proteins with novel functionalities is gaining momentum, driven by advances in computational tools and synthetic biology approaches.
  6. Membrane Protein Dynamics:
    Research is increasingly focused on understanding the dynamics and interactions of membrane proteins, particularly in the context of their roles in signaling and transport.

Declining or Waning

While the Biophysical Journal continues to explore a wide range of topics, certain areas of research appear to be experiencing a decline in focus, possibly due to shifting trends in the broader field of biophysics and molecular biology.
  1. Traditional Biochemical Methods:
    The reliance on conventional biochemical assays is waning as more researchers turn to advanced imaging and computational methods that provide greater insights into molecular dynamics.
  2. Static Structural Studies:
    There is a noticeable decrease in publications focusing solely on static structures, as the field gravitates towards studies that incorporate dynamic and functional aspects of biomolecules.
  3. In Vitro Studies:
    As in vivo and organoid models gain popularity, the emphasis on purely in vitro studies is diminishing, reflecting a trend towards more physiologically relevant experimental systems.
  4. Basic Enzyme Kinetics:
    Research on fundamental enzyme kinetics is becoming less prominent as studies increasingly emphasize complex interactions and regulatory mechanisms in cellular contexts.

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