ACTA PHARMACOLOGICA SINICA
Scope & Guideline
Advancing Pharmacological Frontiers
Introduction
Aims and Scopes
- Pharmacodynamics and Pharmacokinetics:
Research on the mechanisms of drug action, including absorption, distribution, metabolism, and excretion of drugs, to understand their therapeutic effects and side effects. - Molecular Pharmacology:
Investigations into the molecular mechanisms underlying drug interactions with biological systems, contributing to the identification of new drug targets. - Translational Medicine:
Studies that bridge the gap between laboratory research and clinical application, focusing on how laboratory findings can inform clinical practice and improve patient outcomes. - Neuropharmacology:
Research dedicated to understanding how drugs affect the nervous system, including studies on neurodegenerative diseases, pain management, and psychiatric disorders. - Natural Products and Traditional Medicines:
Exploration of pharmacological properties of natural compounds and traditional medicines, including their potential therapeutic applications and mechanisms of action. - Cancer Pharmacology:
Research focused on the mechanisms of action of anti-cancer agents, drug resistance, and the development of novel therapeutic strategies for cancer treatment. - Immunopharmacology:
Studies examining the interplay between pharmacological agents and the immune system, including the development of immunotherapies for various diseases.
Trending and Emerging
- Ferroptosis and Cell Death Mechanisms:
Research focusing on ferroptosis, a form of regulated cell death, has surged, particularly in relation to cancer treatment and neurodegenerative disease mechanisms. - Microbiome and Drug Interactions:
Studies exploring the relationship between gut microbiota and drug metabolism or therapeutic effects are increasingly prominent, highlighting the importance of microbiome research in pharmacology. - Targeted and Personalized Medicine:
There is a growing emphasis on targeted therapies and personalized medicine approaches, particularly in oncology, reflecting advances in understanding individual patient responses to treatment. - Nanomedicine and Drug Delivery Systems:
Innovative drug delivery systems utilizing nanotechnology are gaining attention, particularly for their potential to enhance therapeutic efficacy and reduce side effects. - Immunotherapy Approaches:
Research into immunotherapeutic strategies, especially for cancer treatment, is on the rise, reflecting the success of immune checkpoint inhibitors and CAR-T cell therapies. - Biomarker Discovery and Application:
The identification and application of biomarkers for predicting drug response and disease progression are trending, emphasizing the integration of biomarkers in clinical pharmacology. - Neuroinflammation and CNS Disorders:
Increased research on neuroinflammation and its role in central nervous system disorders is emerging, particularly in the context of developing new therapeutic strategies.
Declining or Waning
- Basic Pharmacological Studies:
There has been a noticeable decline in purely basic pharmacological studies that do not translate to clinical relevance, as researchers increasingly prioritize translational and applied research. - Pharmacogenetics:
While pharmacogenetics remains important, the frequency of studies specifically targeting genetic determinants of drug response has decreased, possibly due to the rising focus on broader systems biology approaches. - Drug Development Process:
Research specifically detailing the early drug development phases has seen reduced coverage, as more studies focus on late-stage clinical trials and real-world applications. - Toxicology Studies:
Studies solely focused on the toxicological aspects of drugs without a clear therapeutic angle are less frequently published, reflecting a shift towards understanding therapeutic windows and drug safety in clinical contexts.
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