CHEMICO-BIOLOGICAL INTERACTIONS
Scope & Guideline
Advancing Understanding in Pharmacology and Toxicology
Introduction
Aims and Scopes
- Chemical Toxicology:
Research examining the toxic effects of various chemicals, including drugs, environmental pollutants, and natural products on biological systems and their underlying mechanisms. - Pharmacokinetics and Drug Interactions:
Studies on the metabolic pathways of drugs, their interactions with enzymes, and implications for therapeutic efficacy and safety. - Cancer Biology and Therapeutics:
Investigations into the molecular mechanisms of cancer, including the development of novel therapeutic agents and the evaluation of their efficacy against various cancer types. - Nanotechnology in Medicine:
Exploration of nanomaterials and their applications in drug delivery systems, therapeutic agents, and diagnostics. - Neuropharmacology and Neurotoxicity:
Research focusing on the effects of chemical substances on the nervous system, including neuroprotective agents and the mechanisms of neurotoxic effects. - Oxidative Stress and Inflammation:
Studies that explore the role of oxidative stress and inflammatory processes in disease pathology and the development of therapeutic interventions. - Natural Products Chemistry:
Isolation and characterization of bioactive compounds from natural sources and their potential applications in health and disease.
Trending and Emerging
- Ferroptosis and Cell Death Mechanisms:
Research on ferroptosis, a form of regulated cell death distinct from apoptosis, has gained momentum, with studies exploring its implications in cancer and neurodegenerative diseases. - Drug Repurposing and Combination Therapies:
There is an increasing interest in repurposing existing drugs for new therapeutic applications, particularly in oncology, as well as exploring synergistic effects of drug combinations. - Role of Microbiota in Health and Disease:
The influence of gut microbiota on health, disease mechanisms, and drug metabolism is becoming a significant area of investigation, reflecting a broader understanding of systemic interactions. - Biochemical Pathways in Disease:
Emerging research is focusing on detailed biochemical pathways involved in various diseases, particularly those linked to inflammation, oxidative stress, and metabolic disorders. - Nanoparticle Applications in Drug Delivery:
The use of nanoparticles for targeted drug delivery and their role in enhancing the bioavailability and efficacy of therapeutic agents is an area of increasing research interest. - Computational Toxicology and Drug Design:
Advancements in computational methods for predicting chemical interactions, toxicity, and drug design are trending, allowing for more efficient screening of potential therapeutic agents.
Declining or Waning
- Traditional Herbal Remedies:
Research focusing on the efficacy of traditional herbal remedies has decreased, possibly due to a shift towards more synthetic and biotechnological approaches in drug development. - Environmental Toxicology of Metals:
While still relevant, studies specifically targeting the environmental toxicology of heavy metals have become less frequent, as the field expands to encompass broader environmental impacts and novel pollutants. - Basic Mechanistic Studies:
There appears to be a waning interest in purely mechanistic studies that do not translate into therapeutic applications, as the emphasis shifts towards translational research and clinical relevance. - In Vitro Models of Disease:
The reliance on traditional in vitro models has seen a decline, with a growing preference for more complex systems such as organ-on-a-chip technologies and 3D culture systems that better mimic in vivo conditions.
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