AMERICAN JOURNAL OF SURGICAL PATHOLOGY
Scope & Guideline
Exploring Innovations in Disease Mechanisms
Introduction
Aims and Scopes
- Molecular Pathology:
Research that investigates the molecular mechanisms underlying various diseases, including cancer, with a focus on genetic alterations and their clinical implications. - Histopathological Evaluation:
Detailed studies on the histological features of tumors and other lesions, providing insights into their classification, diagnosis, and prognostic significance. - Immunohistochemistry:
Exploration of the utility of immunohistochemical markers in differentiating various neoplasms and understanding tumor behavior. - Clinical Correlation:
Investigating the relationship between pathological findings and clinical outcomes, enhancing the understanding of disease progression and treatment responses. - Emerging Tumor Entities:
Focus on newly recognized tumors and variants, including their characterization and implications for diagnosis and treatment. - Artificial Intelligence in Pathology:
Research on the application of AI technologies for enhancing diagnostic precision and efficiency in surgical pathology.
Trending and Emerging
- Genetic and Genomic Profiling:
There is a growing trend towards the use of genomic sequencing and profiling techniques to understand tumor biology and guide treatment decisions. - Tumor Microenvironment Studies:
Research is increasingly addressing the role of the tumor microenvironment in cancer progression and response to therapy, highlighting its significance in pathology. - Precision Medicine and Personalized Pathology:
Emerging focus on how molecular and genetic information can tailor treatment strategies, making pathology a critical component in the era of precision medicine. - Artificial Intelligence in Diagnostics:
The integration of AI tools into diagnostics is rapidly growing, enhancing the accuracy and efficiency of pathological evaluations. - Immune Profiling in Tumors:
Research on the immune landscape of tumors, including the role of immune checkpoints and microenvironmental factors, is becoming increasingly prominent.
Declining or Waning
- Traditional Histopathological Techniques:
There has been a shift towards molecular and genetic characterization, leading to a waning emphasis on classical histopathological techniques alone. - General Tumor Classification Systems:
As molecular profiling becomes more central, broad tumor classification systems are becoming less relevant, with a focus shifting towards specific molecular alterations. - Non-molecular Diagnostic Criteria:
Traditional diagnostic criteria that do not incorporate molecular data are being phased out in favor of more integrated approaches that consider genetic and epigenetic factors.
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