BIOPHARMACEUTICS & DRUG DISPOSITION
Scope & Guideline
Advancing the Science of Drug Disposition
Introduction
Aims and Scopes
- Pharmacokinetics and Pharmacodynamics:
The journal emphasizes studies that explore the pharmacokinetic and pharmacodynamic profiles of drugs, including their absorption, distribution, metabolism, and excretion (ADME) characteristics in various populations and conditions. - Physiologically-Based Pharmacokinetic (PBPK) Modeling:
A significant focus is on the development and application of PBPK models to predict drug behavior across different species and populations, facilitating better drug development and personalized medicine. - Drug-Drug Interactions and Metabolism:
Research on the interactions between drugs, particularly those mediated by metabolic enzymes and transporters, is a core area of interest, providing insights into safety and efficacy. - Biopharmaceutical Characterization:
The journal publishes studies on the biopharmaceutical properties of drug formulations, including novel drug delivery systems and their impact on pharmacokinetics. - Clinical Applications and Case Studies:
It also includes clinical studies that illustrate the application of pharmacokinetic principles in real-world settings, particularly in special populations such as pediatrics and the elderly.
Trending and Emerging
- Integration of Artificial Intelligence and Machine Learning:
Recent publications show a growing trend in the application of AI and machine learning techniques to enhance drug development processes, particularly in predicting pharmacokinetic behaviors. - Focus on Special Populations:
There is an increasing emphasis on pharmacokinetics in special populations, including pediatrics, geriatrics, and patients with comorbidities, reflecting a broader understanding of individualized therapy. - In Vitro-In Vivo Extrapolation (IVIVE) Studies:
The use of IVIVE approaches to predict human pharmacokinetics from animal data is trending, which aligns with the need for more efficient drug development pathways. - Advancements in Drug Delivery Systems:
Innovative drug delivery methods, such as nanotechnology and sustained-release formulations, are gaining prominence, focusing on improving bioavailability and therapeutic outcomes. - Environmental and Ecological Pharmacokinetics:
Emerging research is increasingly exploring the pharmacokinetics of drugs in environmental contexts, addressing concerns related to drug residues and ecological impacts.
Declining or Waning
- Traditional Drug Metabolism Studies:
There has been a noticeable decrease in the publication of studies solely focused on traditional in vitro drug metabolism assays, as newer methodologies such as PBPK modeling become more prevalent. - General Population Pharmacokinetics:
Research centered on general population pharmacokinetics without consideration for specific subpopulations (like pediatrics or geriatrics) appears to be waning, reflecting a shift towards more tailored pharmacokinetic studies. - Basic Mechanistic Studies without Clinical Relevance:
Papers that do not bridge the gap between basic mechanistic studies and clinical relevance are becoming less common, as the journal emphasizes translational research that directly impacts clinical practice.
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