CURRENT DRUG METABOLISM
Scope & Guideline
Shaping the Future of Drug Development and Safety
Introduction
Aims and Scopes
- Drug Metabolism Mechanisms:
Exploration of the biochemical processes involved in drug metabolism, including the roles of enzymes like cytochrome P450, phase I and phase II reactions, and genetic polymorphisms affecting drug metabolism. - Pharmacokinetics and Drug Interaction Studies:
Investigation of the absorption, distribution, metabolism, and excretion (ADME) of drugs, including studies on drug-drug interactions and their clinical implications. - Innovative Drug Delivery Systems:
Research on novel drug delivery methods, including nanotechnology and biomimetic systems, aimed at improving therapeutic outcomes and targeting specific tissues or cells. - Pharmacogenomics and Personalized Medicine:
Examination of how genetic variations affect individual responses to drugs, with implications for personalized treatment strategies and drug development. - Environmental and Physiological Influences on Drug Metabolism:
Studies investigating how external factors like altitude, diet, and microbiota interactions influence drug metabolism and pharmacokinetics.
Trending and Emerging
- Nanotechnology in Drug Delivery:
There is a growing body of work focused on the application of nanotechnology for drug delivery systems, which aim to enhance the bioavailability and targeting of therapeutics. - Machine Learning and AI in Pharmacokinetics:
The incorporation of machine learning and artificial intelligence in predicting drug metabolism and pharmacokinetics is increasingly prominent, showcasing the potential for computational tools in drug development. - Impact of Gut Microbiota on Drug Metabolism:
Research exploring the role of gut microbiota in modulating drug metabolism and pharmacokinetics is gaining traction, emphasizing the importance of microbiome interactions in therapeutic outcomes. - Environmental Pharmacology:
Emerging studies examine the effects of environmental factors, such as altitude and pollution, on drug metabolism and pharmacokinetics, reflecting a broader interest in how external environments influence drug actions.
Declining or Waning
- Traditional Herbal Medicine Interactions:
Research on the interactions between herbal medicines and conventional drugs has decreased, possibly due to a growing emphasis on clinical pharmacology and evidence-based studies. - Basic Mechanistic Studies of Drug Metabolism:
There appears to be a waning interest in purely mechanistic studies without translational applications, as the focus shifts toward clinically relevant findings and implications. - In vitro Metabolism Studies:
The frequency of in vitro studies using liver microsomes or cell lines has declined, as researchers increasingly prefer in vivo studies or physiologically-based pharmacokinetic (PBPK) modeling that provide more clinically relevant data.
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