CANCER AND METASTASIS REVIEWS
Scope & Guideline
Transforming Insights into Effective Therapies
Introduction
Aims and Scopes
- Mechanisms of Cancer Metastasis:
The journal extensively covers the biological mechanisms underlying cancer metastasis, including cellular signaling pathways, genetic alterations, and the role of the tumor microenvironment. - Immunotherapy and Targeted Therapy:
A significant focus is placed on the development and application of immunotherapies and targeted therapies, exploring their mechanisms of action, efficacy, and resistance in various cancer types. - Cancer Cell Plasticity and Heterogeneity:
Research on cancer cell plasticity, stemness, and tumor heterogeneity is a core area, highlighting how these factors contribute to treatment resistance and disease progression. - Biomarkers and Therapeutic Targets:
The journal emphasizes the identification and validation of biomarkers for early detection, prognosis, and therapeutic targeting, aiming to enhance personalized medicine approaches. - Role of the Microbiome and Metabolism:
Emerging themes include the influence of the microbiome on cancer progression and therapy response, as well as the metabolic adaptations of cancer cells. - Clinical Implications and Translational Research:
The journal seeks to bridge the gap between basic research and clinical applications, providing insights into how laboratory findings can inform clinical practice and improve patient outcomes.
Trending and Emerging
- Microbiome and Cancer Interactions:
There is a growing interest in the role of the microbiome in cancer initiation, progression, and response to therapy, highlighting how microbial communities can influence tumor biology. - Innovations in Immunotherapy:
Immunotherapy continues to be a major focus, with emphasis on novel immune checkpoint inhibitors, CAR T-cell therapies, and their applications in various cancer types, particularly in solid tumors. - Metabolic Reprogramming in Cancer:
Research into the metabolic adaptations of cancer cells and their implications for therapy is on the rise, reflecting a deeper understanding of cancer metabolism's role in tumor growth and resistance. - Tumor Microenvironment Dynamics:
The interactions between tumor cells and their microenvironment, including immune cells, stromal cells, and extracellular matrix components, are increasingly recognized as critical in cancer progression and therapy. - Cancer Cell Plasticity and Drug Resistance:
Emerging studies are focusing on the plasticity of cancer cells and their ability to adapt to therapeutic pressures, contributing to drug resistance and treatment failure. - Epigenetic Regulation in Cancer:
Research on epigenetic modifications and their role in cancer progression and treatment response is gaining traction, providing new avenues for therapeutic intervention.
Declining or Waning
- Traditional Chemotherapy Mechanisms:
Research specifically focused on traditional chemotherapy mechanisms has become less prevalent, as there is a growing emphasis on novel therapeutic approaches, such as immunotherapy and precision medicine. - Basic Cellular Biology without Context of Cancer:
Studies centered on basic cellular biology that do not directly relate to cancer mechanisms or treatment implications are appearing less frequently, indicating a shift towards more applied research. - Single-Agent Therapies:
The trend towards combination therapies and multi-modal approaches has overshadowed research focused solely on single-agent therapies, which may be seen as less effective in the context of complex cancer biology. - Historical Perspectives on Cancer Treatments:
Papers that provide historical overviews of cancer treatments without new insights or contextual relevance are decreasing, as the field moves towards more forward-looking research.
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