Cardiovascular Toxicology
Scope & Guideline
Transforming toxicological knowledge into cardiovascular solutions.
Introduction
Aims and Scopes
- Cardiotoxicity Mechanisms:
Research investigating the molecular and cellular mechanisms underlying cardiotoxicity, particularly those induced by chemotherapeutic agents, environmental toxins, and other pharmacological agents. - Therapeutic Interventions:
Studies focusing on potential protective strategies and therapeutic approaches to mitigate cardiotoxic effects, including the evaluation of natural compounds, pharmacological agents, and lifestyle interventions. - Environmental and Occupational Health:
Exploration of the impact of environmental pollutants and occupational exposures on cardiovascular health, including studies on heavy metals, particulate matter, and other toxic substances. - Genetic and Epigenetic Factors:
Research examining the role of genetic predispositions and epigenetic modifications in susceptibility to cardiotoxicity and cardiovascular diseases. - Innovative Diagnostic Tools:
Development and validation of novel diagnostic methods, including biomarkers and imaging techniques, for early detection and prediction of cardiotoxicity in various patient populations.
Trending and Emerging
- Nanoparticle Toxicology:
Research into the cardiotoxic effects of nanoparticles and their protective strategies is gaining momentum, driven by the increasing use of nanotechnology in medicine and environmental applications. - Role of Circular RNAs and Non-coding RNAs:
Emerging studies are focusing on the role of circular RNAs and other non-coding RNAs in modulating cardiotoxic responses, indicating a growing interest in the regulatory mechanisms of gene expression in cardiovascular health. - Impact of Lifestyle Factors:
There is an increasing focus on how lifestyle interventions, such as diet, exercise, and fasting, can mitigate cardiotoxicity, reflecting a holistic approach to cardiovascular health. - Integrative Approaches to Cardiotoxicity:
The integration of multi-omics technologies (genomics, proteomics, metabolomics) to study cardiotoxicity is trending, allowing for a comprehensive understanding of interactions at various biological levels. - Machine Learning in Predicting Cardiotoxicity:
The application of machine learning algorithms to predict cardiotoxic outcomes is an emerging theme, showing the journal's commitment to incorporating advanced computational methods in cardiovascular research.
Declining or Waning
- Traditional Cardiovascular Pharmacology:
Research on classic cardiovascular drugs and their toxicological profiles has decreased, possibly due to a shift towards more contemporary therapeutic agents and innovative drug classes. - Animal Models of Cardiotoxicity:
While still relevant, studies exclusively using traditional animal models for cardiotoxicity assessment appear to be declining, as researchers increasingly adopt advanced in vitro techniques and humanized models. - Generalized Toxicology Studies:
Broad toxicological assessments that do not specifically address cardiovascular implications are less frequently published, indicating a more focused approach on cardiovascular-specific toxicological research. - Epidemiological Studies Without Mechanistic Insight:
Epidemiological research that lacks a mechanistic understanding of cardiovascular toxicity is becoming less common, as the field emphasizes studies that elucidate underlying biological processes.
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