EXPERT OPINION ON THERAPEUTIC TARGETS
Scope & Guideline
Transforming clinical biochemistry with expert-driven knowledge.
Introduction
Aims and Scopes
- Molecular Target Discovery:
The journal emphasizes the identification and validation of new molecular targets for therapeutic intervention, exploring pathways involved in disease mechanisms. - Therapeutic Strategies and Innovations:
It covers innovative therapeutic approaches, including drug repurposing, combination therapies, and strategies to overcome drug resistance in various diseases. - Translational Research:
The focus is on bridging the gap between laboratory research and clinical applications, providing insights into how preclinical findings can be translated into effective therapies. - Comprehensive Reviews and Perspectives:
The journal publishes comprehensive reviews that synthesize current knowledge on therapeutic targets, offering perspectives on future research directions and clinical implications. - Interdisciplinary Approaches:
It encourages interdisciplinary research that integrates molecular biology, pharmacology, and clinical research to address complex health issues.
Trending and Emerging
- Targeting the Tumor Microenvironment:
There is a growing focus on understanding and targeting the tumor microenvironment, which plays a crucial role in cancer progression and therapeutic resistance. - Immunotherapy and Immune Modulation:
Research on immunotherapeutic approaches, including immune checkpoint inhibitors and CAR-T cell therapies, is gaining momentum as novel strategies to enhance anti-tumor immunity. - Epigenetic Modulation:
The exploration of epigenetic modifications and their potential as therapeutic targets is becoming increasingly prominent, indicating a shift towards understanding gene regulation in disease treatment. - MicroRNA and Non-Coding RNAs:
The therapeutic potential of microRNAs and other non-coding RNAs is emerging as a significant theme, highlighting their role in gene expression regulation and disease pathology. - AI and Computational Drug Discovery:
The integration of artificial intelligence and computational methods in drug discovery processes is trending, offering innovative ways to identify and validate therapeutic targets.
Declining or Waning
- Traditional Drug Discovery Approaches:
There has been a noticeable decline in publications focusing on traditional drug discovery methods, as the field shifts towards more targeted and personalized therapeutic strategies. - Single-Agent Therapies:
Research on single-agent therapies is becoming less prominent, with a growing emphasis on combination therapies that leverage multiple mechanisms of action for improved efficacy. - Basic Mechanistic Studies:
While understanding basic mechanisms remains important, there is a waning focus on purely mechanistic studies without direct implications for therapeutic application. - Lack of Novelty in Established Targets:
As certain therapeutic targets become well-established, the novelty of research in these areas appears to be declining, leading to fewer publications on previously identified targets. - Focus on Rare Diseases:
Publications addressing rare diseases as therapeutic targets are less frequent, potentially due to a broader focus on more prevalent conditions with larger patient populations.
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