INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
Scope & Guideline
Bridging Theory and Application in Organic Chemistry
Introduction
Aims and Scopes
- Synthesis of Heterocyclic Compounds:
The journal consistently publishes papers on the synthesis of various heterocyclic compounds, highlighting innovative synthetic methodologies such as microwave-assisted synthesis, ultrasound-assisted synthesis, and one-pot multicomponent reactions. - Biological Evaluation:
A significant portion of the research focuses on evaluating the biological activities of synthesized compounds, including antibacterial, antifungal, anticancer, and antitubercular activities, often backed by molecular docking studies. - Molecular Docking and Computational Studies:
Many articles feature computational studies, including molecular docking, which aids in understanding the interactions between synthesized compounds and biological targets, providing insights into their potential efficacy. - Coordination Chemistry:
The journal explores coordination compounds with heterocyclic ligands, discussing their synthesis, characterization, and potential applications in catalysis and medicinal chemistry. - Green Chemistry Approaches:
There is a noticeable emphasis on sustainable and environmentally friendly synthetic methods, such as metal-free reactions and the use of green solvents, aligning with current trends in reducing the environmental impact of chemical synthesis.
Trending and Emerging
- Antimicrobial and Anticancer Agents:
There is a noticeable increase in research focused on the synthesis of heterocyclic compounds with potential antimicrobial and anticancer properties, driven by the global need for new therapeutic agents. - Metal-Free and Green Synthesis:
Emerging trends show a strong emphasis on eco-friendly and sustainable synthetic methods, such as metal-free reactions and green catalysts, which are gaining traction among researchers aiming to reduce chemical waste. - Multicomponent Reactions:
The popularity of multicomponent reactions is on the rise, as evidenced by multiple publications employing this approach to synthesize complex heterocycles efficiently, which aligns with the trends towards simplifying synthetic pathways. - In Silico Studies and Drug Design:
Research incorporating in silico methods for drug design and molecular docking studies is becoming increasingly prevalent, reflecting a shift towards computational chemistry as a critical tool in drug discovery. - Coordination Compounds and Catalysis:
There is a growing interest in the synthesis and application of coordination compounds derived from heterocycles, particularly in catalytic processes, indicating a trend towards interdisciplinary research that bridges organic and inorganic chemistry.
Declining or Waning
- Natural Product Synthesis:
Research on the synthesis of natural products, particularly those not directly related to heterocycles, has decreased, suggesting a shift towards more synthetic and medicinal chemistry applications that prioritize novel heterocyclic compounds. - Traditional Synthetic Methods:
There appears to be a waning interest in traditional synthetic methods, with fewer papers focusing on classical techniques in favor of modern approaches like microwave and ultrasound-assisted synthesis. - Basic Physical Chemistry Studies:
Studies centered purely on physical chemistry aspects without a direct application to heterocyclic compounds or biological activity have become less frequent, indicating a move towards more applied research.
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