JOURNAL OF APPLIED TOXICOLOGY
Scope & Guideline
Connecting Researchers to the Future of Toxicology
Introduction
Aims and Scopes
- Toxicological Mechanisms and Pathways:
Research examining the biochemical and molecular mechanisms underlying toxicity, including oxidative stress, apoptosis, and inflammation, particularly in response to environmental pollutants, drugs, and nanomaterials. - Risk Assessment and Safety Evaluation:
Studies aimed at assessing the safety and potential health risks associated with exposure to chemicals, pharmaceuticals, and environmental toxins, often employing in silico modeling and quantitative risk assessment methods. - Nanotoxicology and Material Safety:
Investigations into the toxicological effects of nanomaterials, focusing on their interactions with biological systems and potential implications for human health and the environment. - Developmental and Reproductive Toxicity:
Research exploring the effects of toxic exposures on reproductive health and developmental processes, highlighting the implications for both human health and ecological balance. - Ecotoxicology and Environmental Impact:
Studies assessing the impact of pollutants on ecosystems, including aquatic and terrestrial models, to understand the broader implications of toxic exposures in environmental contexts. - Innovative Testing Methods:
Development and validation of novel in vitro and in vivo testing methodologies to improve the predictive capacity of toxicological assessments, including the use of organ-on-a-chip technologies.
Trending and Emerging
- Nanomaterials and Nanotoxicology:
Research on the safety and toxicological effects of nanomaterials is rapidly increasing, driven by their widespread use in various industries and the need to understand their unique interactions with biological systems. - Environmental and Ecotoxicological Impacts:
There is a growing emphasis on the environmental impacts of pollutants, particularly concerning microplastics and their toxicological effects on aquatic life, reflecting heightened awareness of ecological health. - Machine Learning and Computational Toxicology:
The application of machine learning techniques to predict toxicity and assess chemical safety is on the rise, as researchers seek to leverage big data for more efficient and accurate risk assessments. - Endocrine Disruption and Reproductive Toxicity:
Increased attention is being paid to the effects of endocrine-disrupting chemicals on reproductive health, with a focus on understanding mechanisms and long-term consequences of exposure. - Integrated Approaches to Testing and Assessment (IATA):
The adoption of integrated testing strategies that combine in vitro, in silico, and in vivo data is trending, promoting a more comprehensive understanding of chemical toxicity and risk. - Public Health and Occupational Toxicology:
Research focusing on the impact of environmental toxins on public health, particularly in occupational settings, is gaining momentum, reflecting societal concerns about exposure risks and health outcomes.
Declining or Waning
- Traditional Chemical Toxicology:
Research focused solely on traditional chemical agents has declined, as there is a growing emphasis on the effects of complex mixtures and environmental interactions rather than isolated chemical assessments. - In Vivo Animal Testing:
The journal has seen a decrease in studies relying exclusively on traditional in vivo animal testing methods, reflecting a broader trend towards alternative testing strategies that reduce animal use and enhance human relevance. - Single Endpoint Toxicity Assessments:
There is a waning interest in studies that focus on single endpoints of toxicity, such as mortality or a single biochemical marker, as researchers increasingly adopt more holistic approaches that consider multiple biological outcomes. - Historical Toxicology Reviews:
The publication of retrospective reviews on historical toxicological data has diminished, as the focus has shifted towards contemporary research and emerging contaminants, particularly those related to nanomaterials and novel chemicals.
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