JOURNAL OF CONTROLLED RELEASE
Scope & Guideline
Exploring the frontiers of pharmaceutical science.
Introduction
Aims and Scopes
- Drug Delivery Systems:
Research on various drug delivery systems including nanoparticles, liposomes, hydrogels, and microneedles designed to improve the bioavailability and efficacy of therapeutic agents. - Nanomedicine:
Exploration of nanotechnology applications in medicine, focusing on the design, synthesis, and evaluation of nanomaterials for targeted drug delivery and therapy. - Therapeutic Formulations:
Development of innovative formulations that enhance the delivery and release profiles of drugs, including responsive systems that react to specific biological stimuli. - Biomaterials Engineering:
Investigation of biocompatible materials for drug delivery systems, emphasizing the interaction between drugs and the biological environment to optimize therapeutic outcomes. - Clinical Applications:
Translation of laboratory findings to clinical settings, assessing the safety and efficacy of new drug delivery technologies in various therapeutic areas. - Immunotherapy:
Integration of drug delivery systems with immunotherapeutic strategies to enhance the immune response against cancer and other diseases.
Trending and Emerging
- Stimuli-Responsive Drug Delivery:
Research on drug delivery systems that respond to specific stimuli (e.g., pH, temperature, or light) is increasing, enabling more precise control over drug release profiles. - Extracellular Vesicles (EVs):
The use of EVs as drug delivery vehicles is gaining prominence, leveraging their natural ability to facilitate cellular uptake and modulate immune responses. - CRISPR and Gene Editing Technologies:
The integration of CRISPR and other gene editing technologies into drug delivery systems is emerging as a powerful approach for targeted genetic therapies. - Nanomaterials for Cancer Therapy:
Innovative nanomaterials designed for cancer therapy, including those that enhance immunogenicity and target the tumor microenvironment, are rapidly advancing. - Personalized Medicine Approaches:
The shift towards personalized medicine is reflected in research aimed at tailoring drug delivery systems to individual patient needs, improving treatment outcomes. - Combination Therapies:
There is a growing trend in combining different therapeutic modalities (e.g., chemotherapy and immunotherapy) within a single delivery system to enhance therapeutic efficacy.
Declining or Waning
- Conventional Drug Delivery Methods:
There is a noticeable decline in research focused on traditional drug delivery methods as the field shifts towards more innovative approaches like nanotechnology and personalized medicine. - Non-targeted Drug Delivery:
Research on non-targeted delivery systems is decreasing as there is a growing emphasis on targeted therapies that improve specificity and reduce side effects. - Passive Release Mechanisms:
Studies exploring passive release mechanisms are becoming less common, with a trend towards developing stimuli-responsive systems that offer more control over drug release. - Single-Modal Therapies:
The exploration of single-modal therapies is waning as there is a shift towards combination therapies that integrate multiple modalities for enhanced efficacy. - In vitro Models:
There is a reduction in the use of basic in vitro models for drug testing, with more research focusing on complex in vivo models that better mimic human physiology.
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