JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Scope & Guideline
Advancing the Frontiers of Drug Discovery and Therapeutics
Introduction
Aims and Scopes
- Pharmacological Mechanisms:
Research exploring the mechanisms of drug action at various biological targets, including receptor interactions, signaling pathways, and metabolic processes. - Therapeutic Applications:
Studies investigating the efficacy and safety of therapeutic agents in various disease models, emphasizing clinical relevance and translational potential. - Drug Development and Delivery:
Research focused on novel drug formulations, delivery systems, and technologies aimed at improving the pharmacokinetic and pharmacodynamic profiles of therapeutics. - Neuroscience and Behavior:
Papers examining the effects of pharmacological agents on neurological function and behavior, particularly in models of pain, addiction, and neurodegenerative diseases. - Toxicology and Safety Assessment:
Studies evaluating the safety profiles of drugs and their metabolites, including toxicity mechanisms and the impact of environmental factors. - Pharmacogenomics and Personalized Medicine:
Research addressing the genetic and molecular basis of individual responses to drugs, aiming to optimize therapeutic strategies through personalized approaches.
Trending and Emerging
- Nanomedicine and Drug Delivery Systems:
There is a growing trend towards the exploration of nanotechnology in drug delivery, with research focusing on enhancing the efficacy and targeting of therapeutics using nanoparticle systems. - Cannabis and Cannabinoid Research:
An increased focus on the therapeutic potential of cannabinoids in various medical conditions, including pain management and neuroprotection, is evident in recent publications. - Gene Therapy and Biologics:
Research into gene therapy, including the use of RNA-based therapeutics and monoclonal antibodies, has gained traction, reflecting advancements in biopharmaceuticals. - Chronic Pain and Opioid Alternatives:
There is a significant emphasis on identifying non-opioid alternatives for pain management, addressing the opioid crisis through innovative pharmacological strategies. - Translational Pharmacology and Precision Medicine:
Emerging studies are increasingly focusing on translational pharmacology, emphasizing the integration of pharmacogenomics to tailor therapies to individual patient profiles. - Microbiome and Pharmacology:
Research exploring the interactions between the microbiome and pharmacological agents is becoming more prominent, highlighting its implications for drug metabolism and therapeutic outcomes.
Declining or Waning
- Traditional Medicinal Approaches:
Research focusing on classical herbal or traditional medicinal practices appears to have waned, as more emphasis is placed on molecular and mechanistic studies. - Single-Agent Pharmacotherapy:
The interest in studies solely focused on single-agent pharmacotherapy is declining in favor of combination therapies and polypharmacy approaches that consider multi-target strategies. - Basic Pharmacokinetic Studies:
There is a noticeable reduction in the publication of basic pharmacokinetic studies, with an increasing preference for more complex modeling approaches and real-world evidence. - Animal Models of Drug Interaction:
Research centered exclusively on animal models for drug-drug interactions has decreased, likely due to the emerging focus on human-based studies and advanced computational models. - In vitro Studies without Clinical Relevance:
Papers reporting in vitro findings without clear translational implications or clinical relevance are less frequently accepted, reflecting a shift towards applied research.
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