BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Scope & Guideline
Navigating the Complexities of Drug Action and Toxicity
Introduction
Aims and Scopes
- Pharmacological Mechanisms and Drug Actions:
The journal emphasizes studies that elucidate the pharmacological effects of drugs at molecular, cellular, and system levels. This includes research on drug metabolism, pharmacodynamics, and pharmacokinetics, focusing on how drugs exert their therapeutic effects. - Toxicology and Safety Assessments:
Research on the toxicological profiles of pharmaceuticals, including adverse drug reactions, drug interactions, and environmental toxicology. The journal publishes studies evaluating the safety of drugs, including preclinical and clinical toxicology assessments. - Clinical Pharmacology and Therapeutics:
The journal covers clinical studies that assess drug efficacy and safety in human populations. This includes pharmacotherapy, personalized medicine, and the impact of genetic factors on drug responses. - Innovative Drug Development and Delivery Systems:
Research related to new drug formulations, delivery mechanisms, and innovative therapies. This includes studies on nanomedicine, drug repurposing, and advanced therapeutic strategies. - Pharmacogenomics and Personalized Medicine:
The journal publishes articles that explore the influence of genetic variations on drug metabolism and response, highlighting the importance of tailoring pharmacotherapy to individual patients. - Environmental Pharmacology and Ecotoxicology:
Research focusing on the environmental impact of pharmaceuticals and the understanding of drug interactions with ecological systems.
Trending and Emerging
- Neuropharmacology and Neurotoxicity:
A significant increase in studies exploring the pharmacological and toxicological aspects of neurodegenerative diseases, neuroprotection, and the effects of various drugs on neurological health has been observed, reflecting growing concerns over mental health and neurodegenerative disorders. - Pharmacogenomics and Personalized Medicine:
There is a rising interest in research related to pharmacogenomics, with studies focusing on how genetic variations affect drug response, paving the way for personalized medicine approaches tailored to individual genetic profiles. - Drug-Drug Interactions and Polypharmacy:
As polypharmacy becomes more prevalent, especially among older adults, there is an increasing focus on understanding drug-drug interactions and their implications for clinical practice. - Environmental Toxicology and Drug Safety:
Emerging themes include the environmental impact of pharmaceuticals and the safety of drugs in ecological contexts, reflecting growing awareness of the need for sustainable practices in drug development and usage. - Innovative Therapeutics and Drug Delivery Systems:
Research on novel therapeutic agents, including biologics and gene therapies, and advanced drug delivery systems is trending, highlighting the importance of innovation in addressing complex health issues. - Mental Health Pharmacotherapy:
There is an increasing focus on the pharmacological treatment of mental health disorders, particularly in relation to the development and evaluation of new therapeutic strategies for conditions such as depression and anxiety.
Declining or Waning
- Traditional Herbal Medicine:
There has been a noticeable decline in publications focusing on traditional herbal medicines and their pharmacological evaluations, likely due to a shift towards more rigorous clinical and preclinical studies involving synthetic compounds or well-characterized natural products. - Basic Toxicological Studies:
Research that primarily focuses on basic toxicological mechanisms without direct clinical implications appears to be waning. There is a growing preference for studies that connect basic findings to clinical outcomes or therapeutic applications. - Animal Model Studies:
The frequency of studies solely based on animal models without translational aspects has decreased, as there is a stronger push for research that can directly inform human health outcomes. - Pharmaceutical Manufacturing Processes:
Research focused on the manufacturing processes of pharmaceuticals has declined, possibly due to an increasing emphasis on clinical efficacy and safety rather than production methodologies.
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