JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Scope & Guideline
Catalyzing breakthroughs in pharmaceutical safety assessment.
Introduction
Aims and Scopes
- Pharmacokinetics and Pharmacodynamics:
The journal extensively covers studies related to the pharmacokinetic profiles of drugs, including absorption, distribution, metabolism, and excretion (ADME). This includes innovative methodologies for assessing drug efficacy and safety in preclinical models. - Cardiovascular Safety Pharmacology:
A significant focus is placed on cardiovascular safety assessments, utilizing advanced techniques such as telemetry, electrocardiography, and human-induced pluripotent stem cell-derived cardiomyocyte assays to evaluate drug-induced cardiac effects. - Neurotoxicity and CNS Safety:
Research on the central nervous system (CNS) and neurotoxicity is a core area, with methodologies aimed at assessing drug effects on neuronal function and behavior, including in vitro models using human iPSC-derived neurons. - Toxicological Assessments:
The journal publishes findings on various toxicological assessments, including in vivo and in vitro studies evaluating drug safety, adverse effects, and mechanisms of toxicity, thereby providing insights into the safety profiles of pharmaceutical compounds. - Innovative Analytical Techniques:
There is a consistent emphasis on the development and validation of novel analytical techniques such as LC-MS/MS and in silico models, which enhance the reliability and accuracy of pharmacological and toxicological evaluations.
Trending and Emerging
- Human iPSC-Derived Models:
There is a marked increase in research utilizing human-induced pluripotent stem cell (iPSC)-derived models for drug testing, particularly in cardiotoxicity and neurotoxicity assessments, providing more relevant data for human applications. - In Silico Modeling and Computational Approaches:
The integration of in silico modeling techniques for predicting drug interactions and safety profiles is gaining traction, allowing for more efficient drug development processes and risk assessments. - Real-Time Data Monitoring Technologies:
Emerging trends include the use of advanced telemetry and real-time monitoring technologies that enhance the assessment of physiological responses in preclinical studies, improving the accuracy of safety evaluations. - Multi-Modal Drug Safety Assessments:
Research that combines various methodologies, such as electrophysiological assessments, biochemical markers, and imaging techniques, is on the rise, reflecting a holistic approach to drug safety and efficacy evaluations. - Regulatory Science and Best Practices:
There is a growing emphasis on regulatory science and the implementation of best practices in pharmacological testing, aligning research with evolving regulatory frameworks and guidelines to ensure drug safety.
Declining or Waning
- Traditional Toxicology Testing Methods:
There is a noticeable decline in studies utilizing traditional toxicology testing methods, as the field moves towards more innovative and predictive models, particularly those integrating human iPSC technology. - Single Species Animal Models:
Research using single species animal models for pharmacological testing is waning, with a shift towards more complex models that better mimic human physiology and disease states. - Basic Pharmacological Studies:
Basic pharmacological studies that do not incorporate advanced methodologies or translational relevance are less frequently published, reflecting a trend towards more applied and clinically relevant research. - Invasive Procedures in Animal Testing:
There is a gradual decline in the use of invasive procedures for drug testing, as ethical considerations and regulatory changes promote the adoption of non-invasive and reduced-refinement approaches.
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