Medicinal Chemistry

Scope & Guideline

Catalyzing breakthroughs in drug formulation and discovery.

Introduction

Welcome to the Medicinal Chemistry information hub, where our guidelines provide a wealth of knowledge about the journal’s focus and academic contributions. This page includes an extensive look at the aims and scope of Medicinal Chemistry, highlighting trending and emerging areas of study. We also examine declining topics to offer insight into academic interest shifts. Our curated list of highly cited topics and recent publications is part of our effort to guide scholars, using these guidelines to stay ahead in their research endeavors.
LanguageEnglish
ISSN1573-4064
PublisherBENTHAM SCIENCE PUBL LTD
Support Open AccessNo
CountryUnited Arab Emirates
TypeJournal
Convergefrom 2005 to 2024
AbbreviationMED CHEM / Med. Chem.
Frequency8 issues/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
AddressEXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES

Aims and Scopes

The journal 'Medicinal Chemistry' focuses on the exploration and development of new therapeutic agents through innovative chemical research and methodologies. It encompasses a wide range of topics relevant to drug discovery and development, aiming to bridge the gap between chemistry and pharmacology.
  1. Drug Design and Synthesis:
    The journal emphasizes the design and synthesis of new chemical entities with potential therapeutic applications, employing advanced synthetic methodologies and innovative chemical strategies.
  2. Structure-Activity Relationships (SAR):
    Research often includes detailed studies on the structure-activity relationships of compounds, aiming to optimize their pharmacological properties and efficacy.
  3. Biological Evaluation:
    Papers frequently report on the biological evaluation of newly synthesized compounds, including in vitro and in vivo studies, to assess their therapeutic potential against various diseases.
  4. Target Identification and Mechanism of Action:
    The journal covers studies that identify biological targets for new drugs and elucidate their mechanisms of action, contributing to a deeper understanding of drug efficacy.
  5. Natural Products and Derivatives:
    There is a notable interest in the modification and evaluation of natural products, exploring their potential as leads for new drug development.
  6. Interdisciplinary Approaches:
    The journal promotes interdisciplinary research that combines medicinal chemistry with molecular biology, pharmacology, and computational modeling to enhance drug discovery efforts.
The journal has shown a clear trend towards several emerging themes in medicinal chemistry research. These themes reflect the evolving landscape of drug discovery, where innovative approaches and technologies are gaining prominence.
  1. PROTACs and Targeted Protein Degradation:
    There is a growing interest in the development of PROTACs (proteolysis-targeting chimeras) as a novel strategy for targeted protein degradation, which has become a significant focus in cancer therapeutics.
  2. Nanotechnology in Drug Delivery:
    Emerging research highlights the application of nanotechnology for targeted drug delivery systems, enhancing the efficacy and reducing the side effects of therapeutic agents.
  3. Biologics and Bioconjugates:
    The rise of biologics, including monoclonal antibodies and their conjugates, is evident, with research increasingly focusing on their design, synthesis, and therapeutic applications.
  4. Antiviral Drug Development:
    In light of recent global health challenges, there has been a marked increase in research aimed at developing antiviral agents, particularly against emerging viruses like SARS-CoV-2.
  5. Artificial Intelligence in Drug Discovery:
    The integration of artificial intelligence and machine learning in drug design and discovery processes is becoming a prominent theme, facilitating faster and more efficient identification of potential drug candidates.
  6. Focus on Multi-Target Agents:
    There is an emerging trend towards the design of multi-target agents that can simultaneously address multiple pathways or mechanisms, reflecting a shift in the approach to complex diseases.

Declining or Waning

While 'Medicinal Chemistry' remains robust in many areas, certain themes appear to be declining in prevalence within the recent publications. These waning scopes may reflect shifts in research focus or emerging methodologies that overshadow previous approaches.
  1. Traditional Small Molecule Inhibitors:
    Research focusing solely on traditional small molecule inhibitors without novel modifications or innovative delivery systems seems to be less common, as the field shifts towards more complex and multifunctional agents.
  2. Single Target Drug Development:
    There is a noticeable decrease in studies centered around single-target drug development, as the trend moves towards multitargeted approaches and polypharmacology to address complex diseases.
  3. Basic Pharmacokinetic Studies:
    Papers that solely focus on basic pharmacokinetic studies without integrating them into broader drug design or therapeutic efficacy are becoming less common, signaling a shift towards more comprehensive evaluations.
  4. Conventional Synthetic Methodologies:
    The reliance on conventional synthetic methods without exploration of green chemistry or novel synthetic strategies appears to be waning, as there is increasing emphasis on sustainability and efficiency in drug synthesis.

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