Metallomics
Scope & Guideline
Decoding the Role of Metals in Living Systems
Introduction
Aims and Scopes
- Trace Element Homeostasis:
Research exploring how trace elements such as zinc, copper, and iron are regulated within biological systems, including their roles in cellular functions and potential implications for various diseases. - Metal-Protein Interactions:
Studies focusing on the interactions between metals and proteins, particularly metalloproteins, and how these interactions influence biological processes such as enzyme activity, metal transport, and cellular signaling. - Metals in Disease Mechanisms:
Investigations into the role of metals in the pathogenesis of diseases, including neurodegenerative conditions, cancer, and metabolic disorders, highlighting how metal dysregulation can contribute to disease progression. - Innovative Analytical Techniques:
Development and application of advanced analytical methods such as synchrotron X-ray fluorescence, ICP-MS, and laser ablation techniques to study metal distribution and speciation in biological samples. - Environmental Metallomics:
Research addressing the impact of environmental metals and metalloids on biological systems, including studies on bioaccumulation, toxicity, and the role of metals in ecosystems.
Trending and Emerging
- Biomarker Development:
An increasing number of studies are focusing on the use of metal stable isotopes and metalloproteins as potential biomarkers for diseases such as Alzheimer's and cancer, highlighting the translational aspect of metallomics research. - Nanotechnology and Metal-based Therapeutics:
Research into the development of metal-based nanoparticles and complexes for therapeutic applications is on the rise, showcasing innovative approaches to drug delivery and cancer treatment. - Metallomics in Microbial Systems:
Emerging studies are exploring the role of metals in microbial behavior, including metal resistance and homeostasis, reflecting a growing interest in the interactions between metals and microorganisms. - Metallomics and Gut Microbiome Interactions:
There is a notable trend towards understanding how trace metals influence gut microbiota composition and function, linking nutritional aspects of metallomics with health outcomes. - Metals in Aging and Neurodegeneration:
Research focusing on the roles of metals in aging processes and neurodegenerative diseases is gaining traction, emphasizing the need to understand metal homeostasis as a critical factor in health and disease.
Declining or Waning
- Traditional Metal Toxicity Studies:
Research focused solely on the toxicity of metals without considering their biological roles is becoming less frequent as the field shifts towards understanding the nuanced roles of metals in biological systems. - Basic Metal Biochemistry:
Studies that solely describe the biochemical properties of metals without linking them to physiological or pathological processes are seeing reduced publication frequency, as the focus moves towards integrative approaches. - Animal Models in Isolation:
Research utilizing animal models to study metal interactions is declining in favor of more integrated approaches that combine in vitro and in silico methods, reflecting a trend towards more comprehensive and ethically considerate research methodologies.
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