npj Systems Biology and Applications

Scope & Guideline

Pioneering Open Access Research in Systems Biology

Introduction

Welcome to the npj Systems Biology and Applications information hub, where our guidelines provide a wealth of knowledge about the journal’s focus and academic contributions. This page includes an extensive look at the aims and scope of npj Systems Biology and Applications, highlighting trending and emerging areas of study. We also examine declining topics to offer insight into academic interest shifts. Our curated list of highly cited topics and recent publications is part of our effort to guide scholars, using these guidelines to stay ahead in their research endeavors.
LanguageEnglish
ISSN-
PublisherNATURE PORTFOLIO
Support Open AccessNo
Country-
Type-
Converge-
AbbreviationNPJ SYST BIOL APPL / npj Syst. Biol. Appl.
Frequency1 issue/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
AddressHEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY

Aims and Scopes

npj Systems Biology and Applications focuses on advancing the understanding of biological systems through quantitative modeling, computational analysis, and integrative approaches. The journal emphasizes the application of systems biology methodologies to address complex biological questions and improve therapeutic strategies.
  1. Systems Modeling and Simulation:
    The journal publishes research that develops and applies mathematical and computational models to simulate biological processes, from cellular signaling pathways to tumor microenvironments.
  2. Quantitative Analysis of Omics Data:
    A core area of focus is the integration and analysis of multi-omics data (genomics, transcriptomics, proteomics, etc.) to uncover insights into biological functions and disease mechanisms.
  3. Biological Network Dynamics:
    Research on the dynamics of biological networks, including gene regulatory networks and metabolic pathways, is a significant theme, contributing to understanding cellular behavior and interactions.
  4. Therapeutic Development and Drug Discovery:
    The journal emphasizes the use of systems biology approaches to inform drug discovery, including modeling drug responses and identifying potential therapeutic targets.
  5. Personalized Medicine:
    There is a strong focus on personalized medicine, utilizing computational tools to tailor treatments based on individual patient profiles and disease characteristics.
  6. Synthetic Biology and Bioengineering:
    The journal also covers advancements in synthetic biology, including the design of biological systems and the engineering of biomolecular interactions for therapeutic purposes.
Recent publications in the journal highlight a number of trending and emerging themes that reflect the current landscape of systems biology and its applications in health and disease. These themes indicate a shift towards more integrative and technology-driven research.
  1. Artificial Intelligence and Machine Learning in Biology:
    There is an increasing trend towards using AI and machine learning techniques for data analysis, predictive modeling, and drug discovery, enhancing the ability to interpret complex biological data.
  2. Integration of Multi-Omics Approaches:
    Emerging research emphasizes the integration of various omics data types to gain comprehensive insights into biological systems, reflecting a trend towards holistic understanding of cellular functions.
  3. Computational Immunology and Cancer Research:
    A growing focus on computational approaches to immunology and cancer biology is evident, with studies exploring immune responses and therapeutic strategies using systems biology frameworks.
  4. Dynamic Systems and Temporal Modeling:
    There is an increased interest in dynamic modeling approaches that consider the temporal aspects of biological systems, particularly in relation to disease progression and treatment responses.
  5. Synthetic Biology for Therapeutic Applications:
    Research in synthetic biology is gaining momentum, particularly studies that explore the engineering of biological systems for therapeutic interventions, such as engineered T cells and biomolecular circuits.

Declining or Waning

While the journal continues to explore a wide array of themes, certain areas have shown a decline in prominence over recent publications. This shift may reflect evolving scientific priorities or advancements in methodologies that make older approaches less relevant.
  1. Traditional Experimental Biology:
    There is a noticeable decrease in the publication of studies strictly focused on traditional experimental biology methods, as the emphasis has shifted towards computational and systems-based approaches.
  2. Basic Mechanistic Studies without Systems Integration:
    Research that focuses solely on basic mechanistic studies without integrating systems biology perspectives appears to be waning, as there is a growing demand for studies that connect molecular mechanisms to larger biological systems.
  3. Single-Method Approaches:
    Papers that employ single-method approaches, such as purely biochemical assays or isolated cellular studies, have seen a decline in favor of multi-disciplinary research that incorporates computational modeling and systems analysis.

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