PPAR Research

Scope & Guideline

Unlocking the Potential of PPARs in Drug Discovery

Introduction

Welcome to your portal for understanding PPAR Research, featuring guidelines for its aims and scope. Our guidelines cover trending and emerging topics, identifying the forefront of research. Additionally, we track declining topics, offering insights into areas experiencing reduced scholarly attention. Key highlights include highly cited topics and recently published papers, curated within these guidelines to assist you in navigating influential academic dialogues.
LanguageEnglish
ISSN1687-4757
PublisherHINDAWI LTD
Support Open AccessYes
CountryUnited States
TypeJournal
Convergefrom 2006 to 2024
AbbreviationPPAR RES / PPAR Res.
Frequency-
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
AddressADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON W1T 5HF, ENGLAND

Aims and Scopes

PPAR Research focuses on the multifaceted roles of Peroxisome Proliferator-Activated Receptors (PPARs) in various biological processes, particularly in metabolism, inflammation, and cancer biology. The journal emphasizes both basic and applied research that explores the mechanisms of PPAR signaling and its therapeutic implications.
  1. Metabolic Regulation:
    Research on how PPARs influence lipid metabolism, glucose homeostasis, and energy expenditure, highlighting their roles in obesity, diabetes, and metabolic syndrome.
  2. Cancer Biology:
    Exploration of the role of PPARs in cancer progression, chemoresistance, and potential therapeutic targets for various cancers, including breast, colon, and hypopharyngeal cancers.
  3. Inflammation and Oxidative Stress:
    Studies investigating the impact of PPAR activation on inflammatory pathways and oxidative stress, with a focus on their implications for chronic diseases and tissue repair.
  4. Epigenetic Regulation:
    Research on the epigenetic mechanisms that regulate PPAR expression and activity, especially during adipogenesis and other developmental processes.
  5. Therapeutic Applications:
    Development of novel therapeutic strategies targeting PPAR signaling pathways, including the use of natural compounds and synthetic agonists in disease treatment.
Recent publications in PPAR Research indicate a shift towards several emerging themes that reflect current scientific interests and societal health challenges. These themes highlight the expanding role of PPARs in various contexts, emphasizing their potential as therapeutic targets.
  1. PPARs in Cancer Chemosensitivity:
    An increasing number of studies are focusing on the role of PPARs in mediating responses to chemotherapy, suggesting that modulating PPAR activity could enhance treatment efficacy in cancer patients.
  2. Noncoding RNAs and PPAR Interactions:
    Emerging research is investigating the role of noncoding RNAs in regulating PPAR expression and function, indicating a growing interest in the regulatory networks involving PPARs.
  3. PPARs and Gut Microbiota:
    There is a noticeable trend towards exploring the interactions between PPAR signaling and gut microbiota, reflecting an interest in how these relationships impact metabolic health and disease.
  4. Natural Compounds as PPAR Modulators:
    The exploration of natural products and phytochemicals as PPAR agonists or antagonists is gaining traction, particularly for their potential therapeutic applications in metabolic and inflammatory diseases.
  5. PPARs in Neuroprotection and Neuropathic Pain:
    Research is increasingly focusing on the role of PPARs in neurological conditions, particularly their protective effects against neuroinflammation and pain, which may open new avenues for treatment.

Declining or Waning

While PPAR Research has consistently focused on various aspects of PPAR biology, certain themes have seen a decrease in publication frequency or relevance over time. This decline may indicate a shift in research priorities or advancements in understanding PPAR functions.
  1. Basic Mechanistic Studies:
    There appears to be a waning interest in purely mechanistic studies of PPARs without translational implications, as the field shifts towards more clinically relevant research.
  2. Single-Pathway Investigations:
    Research focusing solely on a single PPAR pathway without considering cross-talk with other pathways has become less common, reflecting a broader interest in integrative approaches.
  3. Animal Models for Basic Research:
    The use of traditional animal models for basic research on PPAR functions is declining, likely due to the rise of in vitro studies and patient-derived models that provide more direct relevance to human diseases.

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