ADMET and DMPK
Scope & Guideline
Pioneering research at the intersection of absorption and metabolism.
Introduction
Aims and Scopes
- ADMET Profiling:
Research focusing on the absorption, distribution, metabolism, excretion, and toxicity of drugs, providing insights into their pharmacological behavior and safety. - Drug Formulation and Delivery Systems:
Studies on the development and optimization of drug delivery systems, including nanomaterials and liposomes, aimed at enhancing drug efficacy and bioavailability. - Electrochemical Sensing and Biosensors:
Innovative methodologies involving electrochemical sensors for detecting drug compounds and biomarkers, which are crucial for pharmacokinetic studies and therapeutic monitoring. - Pharmacokinetics and Modeling:
Research involving the modeling of drug pharmacokinetics, including novel approaches to predict drug behavior in vivo, which is essential for drug development. - Nanotechnology in Drug Development:
Exploration of nanotechnology applications in drug formulation, delivery, and diagnostics, highlighting the transformative potential of nanomaterials in enhancing therapeutic outcomes.
Trending and Emerging
- Nanomaterials and Drug Delivery Innovations:
There is an increasing focus on the application of nanomaterials for drug delivery, enhancing bioavailability, and overcoming biological barriers, which is crucial for developing effective therapies. - Electrochemical Biosensors for Biomarker Detection:
The trend towards using advanced electrochemical methods for detecting biomarkers and drugs highlights the importance of rapid and sensitive diagnostic tools in pharmacokinetics. - Sustainable and Green Chemistry Approaches:
Research emphasizing environmentally friendly synthesis methods for drug compounds and materials is gaining traction, reflecting a broader commitment to sustainability in pharmaceutical sciences. - Advanced In Vitro Models for Drug Testing:
The emergence of sophisticated in vitro models, including 3D cell cultures and organ-on-a-chip systems, underscores a shift towards more predictive and ethical approaches in drug testing. - Personalized Medicine and Pharmacogenomics:
An increasing interest in the interplay between genetics and drug response is evident, indicating a trend towards personalized medicine that tailors treatments based on individual genetic profiles.
Declining or Waning
- Traditional Pharmaceutical Formulations:
Research focusing on conventional drug formulation techniques is becoming less frequent as new technologies, particularly nanotechnology and advanced delivery systems, gain traction. - Basic Pharmacological Studies:
Studies that solely focus on basic pharmacological effects without integrating ADMET or DMPK perspectives are declining, as the journal emphasizes comprehensive approaches that include these critical factors. - Animal Studies in Drug Development:
There is a noticeable decrease in studies relying solely on animal models for drug testing, as the field moves towards more ethical and predictive in vitro models, including organ-on-a-chip technologies.
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