AAPS PHARMSCITECH
Scope & Guideline
Delivering Cutting-edge Insights for Public Health Advancements
Introduction
Aims and Scopes
- Innovative Drug Delivery Systems:
Research on novel drug delivery mechanisms, including nanocarriers, liposomes, emulsions, and solid lipid nanoparticles aimed at enhancing bioavailability and targeting specific tissues. - Formulation Development:
Studies focusing on the design, optimization, and characterization of pharmaceutical formulations, including solid dosage forms, liquid formulations, and topical applications. - Pharmacokinetics and Drug Absorption:
Investigations into the absorption, distribution, metabolism, and excretion (ADME) of drugs, utilizing both in vitro and in vivo models to predict human pharmacokinetics. - Quality by Design (QbD):
Application of QbD principles in pharmaceutical development, ensuring robust formulation processes and consistent product quality through systematic risk assessment and optimization. - Nanotechnology in Pharmaceuticals:
Exploration of nanotechnology applications in drug formulation, including the development of nanocrystals, nanoemulsions, and nanosuspensions to overcome solubility challenges. - Biopharmaceutical and Regulatory Considerations:
Research addressing biopharmaceutical performance and regulatory aspects related to drug formulations, particularly in the context of generic and innovative products.
Trending and Emerging
- Advanced Drug Delivery Systems:
Research focused on smart and responsive drug delivery systems, such as stimuli-sensitive formulations and targeted delivery mechanisms, is gaining traction. - 3D Printing in Pharmaceuticals:
The application of 3D printing technology for personalized medicine and on-demand drug manufacturing is increasingly featured, showcasing its potential to revolutionize dosage form design. - Artificial Intelligence and Machine Learning:
The integration of AI and machine learning in drug formulation and development processes is emerging as a significant trend, enhancing predictive modeling and optimization. - Nanocarrier-Based Therapeutics:
The development of novel nanocarrier systems for targeted therapy, especially in oncology and chronic disease management, is on the rise, reflecting advancements in nanotechnology. - Sustainability in Pharmaceutical Formulations:
Research addressing environmentally friendly formulations and sustainable practices in drug development is increasingly prevalent, aligning with global sustainability goals. - Personalized Medicine Approaches:
Emerging studies focus on tailored therapeutic strategies, including individualized dosing regimens and patient-specific formulations, reflecting the trend towards personalized healthcare.
Declining or Waning
- Conventional Formulation Techniques:
Traditional methods of formulation development, such as simple mixing and granulation, are being overshadowed by advanced techniques like 3D printing and nanotechnology. - General Drug Stability Studies:
Generic studies focusing solely on drug stability without integrated approaches considering formulation interactions and environmental factors are becoming less common. - Animal Models for Pharmacokinetics:
The reliance on animal studies for pharmacokinetic evaluations is decreasing, with a growing emphasis on in silico modeling and alternative methods. - Standard Dissolution Testing:
Research centered around conventional dissolution testing methods is declining, as there is a shift towards more predictive and biorelevant dissolution methodologies. - Broad-Spectrum Antiviral Research:
While antiviral research remains important, specific studies on broad-spectrum antivirals are becoming less frequent, with a focus shifting towards targeted therapies.
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