Advances in Cancer Biology-Metastasis
Scope & Guideline
Illuminating Mechanisms of Metastatic Progression.
Introduction
Aims and Scopes
- Mechanisms of Metastasis:
The journal focuses on the cellular and molecular mechanisms that facilitate the spread of cancer cells from primary tumors to distant organs, including studies on signaling pathways, cellular interactions, and the tumor microenvironment. - Therapeutic Strategies:
Research published in the journal often explores novel therapeutic approaches aimed at preventing or treating metastatic disease, including targeted therapies, immunotherapies, and combination treatments. - Biomarkers and Diagnostics:
Advances in Cancer Biology-Metastasis highlights studies that identify and validate biomarkers for early detection of metastasis, as well as research on diagnostic techniques that improve patient outcomes. - Tumor Microenvironment:
The journal emphasizes the role of the tumor microenvironment in metastasis, including interactions between tumor cells and stromal cells, immune cells, and extracellular matrix components. - Cancer Genetics and Epigenetics:
Research related to the genetic and epigenetic alterations in cancer cells that contribute to metastatic behavior is a core area of focus, including studies on mutations, gene expression changes, and epigenetic modifications.
Trending and Emerging
- Immunotherapy and Metastasis:
There is a growing interest in the role of immunotherapy in targeting metastatic cancer, including studies on immune checkpoint inhibitors and their effects on metastasis progression. - Liquid Biopsies:
Research into liquid biopsies as a non-invasive method for monitoring metastasis is on the rise, highlighting their potential for early detection and treatment response assessment. - Microbiome and Cancer:
The influence of the microbiome on cancer progression and metastasis is emerging as a significant area of research, exploring how microbial communities affect tumor behavior and patient outcomes. - Metabolic Reprogramming:
Studies examining the metabolic changes that occur in metastatic cancer cells are gaining prominence, with implications for understanding tumor growth and developing new therapeutic strategies. - Artificial Intelligence in Cancer Research:
The application of artificial intelligence and machine learning in analyzing cancer data and predicting metastatic behavior is becoming increasingly relevant, reflecting a trend towards data-driven approaches in cancer biology.
Declining or Waning
- Traditional Chemotherapy Approaches:
There has been a noticeable decline in publications focusing on traditional chemotherapy regimens for metastatic cancer treatment, as research shifts towards more innovative and targeted therapies. - In Vitro Models of Metastasis:
Research utilizing conventional in vitro models to study metastasis is becoming less prevalent, with a growing preference for more complex in vivo models that better mimic the tumor microenvironment. - Single-Agent Therapeutics:
The exploration of single-agent therapies is waning as the field moves towards combination therapies that target multiple pathways to effectively combat metastatic cancer. - Basic Cell Biology of Tumor Cells:
While foundational studies are essential, there has been a reduction in the publication of basic cell biology research without a direct connection to metastasis or therapeutic implications. - Epidemiological Studies:
The focus on epidemiological studies related to cancer metastasis has diminished, likely due to the increasing emphasis on mechanistic and therapeutic research.
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