AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Scope & Guideline
Fostering Innovation in the Heart of Cellular Science.
Introduction
Aims and Scopes
- Cellular Mechanisms of Physiology:
The journal emphasizes studies that elucidate the cellular and molecular mechanisms responsible for physiological processes, including metabolic pathways, signaling cascades, and cellular responses to environmental stimuli. - Pathophysiology and Disease Mechanisms:
Research exploring the alterations in cellular physiology associated with various diseases, such as cancer, diabetes, and cardiovascular disorders, is a core focus, aiming to bridge basic research with clinical implications. - Innovative Experimental Approaches:
The publication encourages the use of cutting-edge techniques, including advanced imaging, omics technologies, and computational modeling, to investigate cellular functions and interactions. - Interdisciplinary Research:
The journal promotes interdisciplinary studies that integrate molecular biology, biochemistry, and biophysics to provide a comprehensive understanding of cell function and its implications in physiological and pathological contexts. - Regenerative Medicine and Tissue Engineering:
There is a growing interest in research related to regenerative medicine and tissue engineering, focusing on the cellular mechanisms of tissue repair and the development of therapeutic strategies.
Trending and Emerging
- Cellular Metabolism and Bioenergetics:
There is a rising interest in understanding the metabolic pathways and bioenergetics of cells, particularly in the context of diseases such as obesity, diabetes, and cancer, highlighting the importance of metabolism in cellular function. - Microbiome and Host Interactions:
Research exploring the interactions between the microbiome and host cellular physiology is gaining traction, emphasizing the role of gut microbiota in health and disease. - Extracellular Vesicles and Cell Communication:
The study of extracellular vesicles as mediators of intercellular communication and their roles in various physiological and pathological processes is an emerging area of interest. - Stem Cell Biology and Regenerative Therapies:
There is an expanding focus on stem cell biology, particularly the mechanisms underlying stem cell differentiation, tissue regeneration, and their applications in regenerative medicine. - Mechanobiology and Cellular Responses to Mechanical Stimuli:
Research into how mechanical forces affect cellular behavior and physiology is trending, with implications for understanding tissue development, repair, and disease mechanisms.
Declining or Waning
- Basic Physiological Studies:
There has been a noticeable decrease in publications dedicated solely to fundamental physiological studies without a clear application to disease or medical relevance, as the journal shifts towards more translational research. - Animal Models of Disease:
The reliance on traditional animal models for physiological studies appears to be waning, with researchers increasingly favoring human-derived or organoid models that better mimic human pathophysiology. - Static Cell Culture Models:
The use of conventional static cell culture systems is declining in favor of more dynamic and physiologically relevant 3D culture systems that better replicate in vivo conditions. - Single-Cell Analysis:
Although single-cell technologies are gaining traction, there has been a relative decline in the publication of studies solely focused on single-cell analysis without integrating other methodologies or broader physiological implications. - Chronic Disease Models:
Research focusing exclusively on chronic disease models without exploring underlying cellular mechanisms or therapeutic interventions is becoming less common, as the journal emphasizes studies with potential clinical applications.
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