CELLULAR SIGNALLING
Scope & Guideline
Elevating Insights into Cellular Communication
Introduction
Aims and Scopes
- Cellular Signaling Mechanisms:
Investigation of the molecular pathways involved in cellular signaling, including receptor activation, second messenger systems, and downstream effectors. - Pathophysiological Implications:
Exploration of how dysregulation in signaling pathways contributes to various diseases, including cancer, cardiovascular disorders, and metabolic diseases. - Therapeutic Targets and Drug Development:
Identification of novel therapeutic targets within signaling pathways and the development of small molecules or biological agents aimed at modulating these pathways for therapeutic benefit. - Role of Non-Coding RNAs:
Analysis of the involvement of non-coding RNAs, including microRNAs and long non-coding RNAs, in the regulation of cellular signaling and their implications in disease. - Intercellular Communication:
Study of how cellular signaling affects intercellular interactions, particularly in the tumor microenvironment and immune responses.
Trending and Emerging
- Ferroptosis and Its Role in Disease:
Research on ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has surged, highlighting its implications in cancer, neurodegeneration, and organ damage. - Exosome-Mediated Signaling:
The exploration of exosomes as mediators of cellular communication and signaling has gained traction, emphasizing their role in cancer progression and potential as biomarkers. - Immunomodulatory Signaling Pathways:
The study of how cellular signaling pathways modulate immune responses, particularly in the context of cancer immunotherapy, has become increasingly prominent. - Integrative Multi-Omics Approaches:
There is a growing trend towards integrating various omics data (genomics, transcriptomics, proteomics) to provide a holistic view of cellular signaling networks and their implications in health and disease. - CircRNAs in Cancer Biology:
Research focusing on circular RNAs (circRNAs) as regulators of gene expression and their roles in cancer has emerged as a significant area of interest, revealing novel mechanisms of action.
Declining or Waning
- Basic Research on Traditional Pathways:
There has been a noticeable decrease in publications focusing solely on well-established signaling pathways (e.g., MAPK, PI3K) without new insights or applications, as the field moves towards more integrative and complex signaling interactions. - Single-Cell Analysis Studies:
Though still important, the frequency of studies solely relying on single-cell analysis techniques has waned as researchers adopt multi-omics approaches that provide a more comprehensive view of cellular signaling. - Studies on Non-Mammalian Models:
Research utilizing non-mammalian model organisms for signaling studies has diminished, likely due to a greater emphasis on mammalian systems that more directly correlate with human health. - In Vitro Studies Without Translational Relevance:
There is a shift away from in vitro studies that do not demonstrate clear translational relevance to human diseases, as the journal increasingly prioritizes research with potential clinical applications.
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