MOLECULAR & CELLULAR PROTEOMICS
Scope & Guideline
Advancing the frontiers of protein science.
Introduction
Aims and Scopes
- Proteomic Methodologies:
The journal publishes research on advanced proteomic techniques, including mass spectrometry, phosphoproteomics, and glycoproteomics, which are essential for the detailed analysis of protein structures, functions, and interactions. - Clinical Applications of Proteomics:
A significant focus is placed on the clinical implications of proteomic findings, particularly in cancer research, where proteomic profiles can inform prognosis and treatment strategies. - Integrative Multi-Omics Approaches:
The integration of proteomics with genomics, transcriptomics, and metabolomics is a core area, facilitating comprehensive insights into biological systems and disease states. - Biomarker Discovery and Validation:
Molecular & Cellular Proteomics serves as a platform for discovering and validating biomarkers for various diseases, enhancing the potential for precision medicine. - Technological Innovations:
Papers often highlight novel tools and methodologies that push the boundaries of traditional proteomics, including single-cell proteomics, spatial proteomics, and advanced bioinformatics solutions.
Trending and Emerging
- Immunopeptidomics:
The field of immunopeptidomics is gaining traction, focusing on the identification and characterization of peptide-MHC interactions, which are critical for understanding immune responses and developing immunotherapies. - Single-Cell Proteomics:
There is an increasing emphasis on single-cell proteomics, allowing for the exploration of cellular heterogeneity and the identification of unique protein signatures at the individual cell level. - Post-Translational Modifications (PTMs):
Research on PTMs, particularly glycosylation and phosphorylation, is trending, as these modifications play crucial roles in protein function and regulation, influencing various biological processes and disease mechanisms. - Proteogenomics:
The integration of proteomics with genomics (proteogenomics) is emerging as a powerful approach for uncovering novel protein-coding genes and understanding the complexities of gene expression and regulation. - Microbiome and Host Interactions:
Studies exploring the proteomic aspects of microbiome-host interactions are on the rise, reflecting a growing interest in how these interactions influence health and disease.
Declining or Waning
- Basic Proteomics Techniques:
There appears to be a waning interest in basic proteomics techniques that do not incorporate advanced methodologies or multi-omics integrations, as the field increasingly values comprehensive and innovative approaches. - Research on Classical Cell Signaling Pathways:
Studies focusing solely on classical signaling pathways without integration with proteomic data have diminished, reflecting a move towards more complex analyses that consider multiple signaling networks and their interactions. - Descriptive Proteomics Studies:
There has been a reduction in purely descriptive studies that do not provide functional insights or clinical relevance, as the field shifts towards more impactful research that addresses specific biological questions.
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