BIOCHEMICAL JOURNAL
Scope & Guideline
Navigating the Complexities of Life at the Molecular Level
Introduction
Aims and Scopes
- Biochemical Mechanisms of Disease:
Research articles frequently explore the biochemical pathways and molecular mechanisms that contribute to various diseases, including cancer, neurodegenerative disorders, and metabolic diseases. - Cellular and Molecular Biology:
The journal emphasizes studies on cellular processes at the molecular level, including signal transduction, gene expression regulation, and protein interactions. - Protein Biochemistry:
Significant attention is given to the structure, function, and dynamics of proteins, including studies on enzyme mechanisms, protein-protein interactions, and the role of post-translational modifications. - Metabolic Pathways:
Research often focuses on metabolic pathways, including those related to energy metabolism, lipid biosynthesis, and carbohydrate metabolism, highlighting their implications for health and disease. - Chemical Biology:
The journal publishes studies that integrate chemical and biological approaches to understand and manipulate biological systems, including drug discovery and the development of therapeutic strategies. - Plant Biochemistry and Physiology:
There is also a notable focus on plant biochemistry, including studies on stress responses, metabolic adaptations, and plant-microbe interactions.
Trending and Emerging
- Molecular Mechanisms of Cancer:
There is a rising focus on understanding the molecular and biochemical underpinnings of cancer, including the roles of specific mutations, signaling pathways, and metabolic alterations in tumor biology. - Neurodegenerative Diseases:
Research into the biochemical mechanisms underlying neurodegenerative diseases, especially related to protein aggregation and mitochondrial dysfunction, has gained traction, reflecting the urgent need for therapeutic strategies. - Metabolic Disorders and Obesity:
Emerging studies are increasingly addressing the biochemical aspects of metabolic disorders, including obesity, diabetes, and related conditions, focusing on metabolic pathways and their regulation. - CRISPR and Genome Editing Technologies:
The use of CRISPR and other genome editing technologies is becoming a prominent theme, with studies exploring their applications in functional genomics and therapeutic interventions. - Synthetic Biology and Biotechnology:
A growing interest in synthetic biology and its applications in biotechnology, including metabolic engineering and the development of novel therapeutic agents, is evident in recent publications. - Microbiome Research:
Research exploring the role of the microbiome in health and disease, particularly its biochemical interactions with host systems, is gaining prominence, reflecting its importance in personalized medicine.
Declining or Waning
- Basic Biochemical Techniques:
Traditional biochemical techniques and methods, such as basic enzyme assays and standard protein purification protocols, appear to be less frequently published, indicating a shift towards more innovative and complex methodologies. - Classical Genetic Studies:
Research focusing exclusively on classical genetics and Mendelian inheritance patterns has become less prominent, as the emphasis shifts towards molecular genetics and genomic approaches. - Microbial Biochemistry:
Studies specifically targeting microbial biochemistry, particularly those focusing on well-characterized model organisms, seem to be declining in favor of more complex systems involving host-pathogen interactions. - In vitro Studies:
There is a noted reduction in purely in vitro studies, with a growing preference for research that incorporates in vivo models or systems biology approaches to reflect more complex biological interactions.
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