Biomarker Research
Scope & Guideline
Exploring the frontiers of disease mechanisms through biomarkers.
Introduction
Aims and Scopes
- Cancer Biomarkers Discovery and Validation:
Focuses on identifying novel biomarkers that can aid in cancer detection, prognosis, and treatment response, employing techniques such as genomic sequencing, proteomics, and metabolomics. - Immunotherapy and Immune Microenvironment:
Examines the role of biomarkers in immunotherapy, including the characterization of tumor-infiltrating lymphocytes, immune checkpoint molecules, and the tumor microenvironment's impact on therapeutic outcomes. - Multi-Omics Approaches:
Utilizes integrated multi-omics strategies (genomics, transcriptomics, proteomics, and metabolomics) to provide comprehensive insights into cancer biology and therapeutic responses. - Liquid Biopsy and Non-Invasive Diagnostics:
Focuses on the development of non-invasive techniques for cancer diagnosis and monitoring, including circulating tumor DNA (ctDNA), exosomes, and other extracellular vesicles as potential biomarkers. - Clinical Applications and Therapeutics:
Discusses the clinical implications of biomarkers in guiding treatment decisions, predicting patient outcomes, and personalizing therapy, particularly in the context of targeted therapies and immunotherapies.
Trending and Emerging
- Single-Cell and Spatial Transcriptomics:
A significant trend towards utilizing single-cell technologies and spatial transcriptomics to understand tumor heterogeneity and the immune microenvironment, providing insights into cellular interactions and therapeutic responses. - Metabolic Biomarkers and Metabolic Reprogramming:
Emerging focus on the role of metabolism in cancer progression and therapy resistance, with studies exploring metabolic reprogramming as a potential therapeutic target. - Artificial Intelligence and Machine Learning in Biomarker Discovery:
The integration of AI and machine learning techniques for analyzing large datasets to discover novel biomarkers and improve diagnostic accuracy is gaining traction. - Liquid Biopsy Advancements:
Increasing attention to liquid biopsies as a non-invasive method for early cancer detection and monitoring treatment responses, with a focus on ctDNA and exosomal biomarkers. - Targeted Therapy and Personalized Medicine:
A growing emphasis on the development of biomarkers that predict response to targeted therapies and immunotherapies, supporting the trend towards personalized cancer treatment.
Declining or Waning
- Traditional Biomarker Discovery Techniques:
The emphasis on classic methods for biomarker discovery, such as single-analyte assays, has decreased in favor of more sophisticated multi-omics and systems biology approaches that provide a more holistic view of cancer. - Non-Specific Biomarkers:
There is a waning interest in non-specific biomarkers that lack robust predictive or prognostic value, as the field moves towards more targeted and precise biomarker applications. - Basic Mechanistic Studies:
Research focused solely on basic mechanistic insights without translational applications is becoming less common, as the journal increasingly prioritizes studies that link basic science to clinical outcomes.
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