CANCER GENE THERAPY
Scope & Guideline
Advancing the Frontier of Cancer Treatment
Introduction
Aims and Scopes
- Gene Therapy Innovations:
Focus on the development and application of various gene therapy techniques, including oncolytic viruses, CAR-T cell therapies, and RNA-based therapeutics. - Molecular Mechanisms and Pathways:
In-depth exploration of the molecular pathways involved in cancer progression, treatment resistance, and the role of genetic modifications. - Tumor Microenvironment Interactions:
Investigation of how the tumor microenvironment influences cancer progression and response to therapies, including the role of extracellular vesicles and immune cells. - Biomarker Discovery and Validation:
Identification and validation of biomarkers for cancer diagnosis, prognosis, and therapeutic response, facilitating personalized medicine approaches. - Translational Research:
Emphasis on translating laboratory findings into clinical applications, including clinical trials of gene therapy techniques and their effectiveness in cancer treatment.
Trending and Emerging
- RNA Modifications and Non-coding RNAs:
Emerging studies highlight the roles of RNA modifications (e.g., m6A) and non-coding RNAs (e.g., circRNAs, lncRNAs) in cancer biology, signaling pathways, and potential therapeutic targets. - Immunotherapy and Tumor Microenvironment Modulation:
Increased focus on immunotherapy strategies, including CAR-T cell therapies and immune checkpoint inhibitors, as well as the role of the tumor microenvironment in modulating immune responses. - Synthetic Lethality Approaches:
Research on synthetic lethality is gaining attention, particularly in the context of targeting specific genetic vulnerabilities in cancer cells, offering new therapeutic strategies. - Targeted Therapy Combinations:
A notable trend towards investigating the efficacy of combination therapies that target multiple pathways or mechanisms simultaneously to overcome resistance and improve patient outcomes. - Personalized and Precision Medicine:
Research is increasingly oriented towards personalized medicine, emphasizing the need for tailored therapies based on individual genomic and molecular profiles.
Declining or Waning
- Traditional Chemotherapy Approaches:
Research related to conventional chemotherapy is less frequently addressed, as the field shifts towards targeted therapies and personalized medicine. - Basic Cancer Biology without Therapeutic Focus:
Studies focusing solely on basic cancer biology without implications for therapeutic development are becoming less prominent in favor of research with direct clinical applications. - Single-Agent Therapies:
There is a waning interest in studies evaluating single-agent therapies, as combination therapies and multi-targeted approaches are increasingly favored. - Epidemiological Studies:
Epidemiological research related to cancer incidence and prevalence is less frequently published, with a greater emphasis on mechanistic and therapeutic studies.
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