Cancer Drug Resistance
Scope & Guideline
Transforming Oncology: Tackling Drug Resistance Head-On.
Introduction
Aims and Scopes
- Mechanisms of Drug Resistance:
The journal extensively covers the various biological and molecular mechanisms that cancer cells employ to evade the effects of anticancer drugs, including genetic mutations, alterations in drug transporters, and changes in metabolic pathways. - Therapeutic Strategies:
It emphasizes innovative therapeutic strategies aimed at overcoming drug resistance, including combination therapies, targeted therapies, and the use of novel drug delivery systems. - Biomarkers and Predictive Factors:
Research published in this journal often explores potential biomarkers that can predict therapeutic response or resistance, thereby aiding in personalized medicine approaches. - Role of Cancer Stem Cells:
The journal highlights the significance of cancer stem cells in drug resistance, exploring how these cells contribute to treatment failure and disease recurrence. - Emerging Technologies and Models:
It discusses new technologies and experimental models used to study drug resistance, including in vitro and in vivo systems that can mimic the tumor microenvironment.
Trending and Emerging
- Immunotherapy Resistance:
There is an increasing emphasis on understanding the mechanisms of resistance to immunotherapy, particularly immune checkpoint inhibitors, as these therapies are becoming more prevalent in cancer treatment. - Role of Non-Coding RNAs:
Research on non-coding RNAs, including circular RNAs and microRNAs, in drug resistance has surged, highlighting their potential as biomarkers and therapeutic targets. - Nanomedicine and Drug Delivery Systems:
The exploration of advanced nanomedicine strategies to overcome drug resistance has gained momentum, with a focus on improving the delivery and efficacy of anticancer agents. - Metabolic Reprogramming:
Studies on metabolic reprogramming in cancer cells as a mechanism of resistance are trending, reflecting a growing understanding of how metabolic pathways can influence treatment outcomes. - Extracellular Vesicles and Intercellular Communication:
Research into the role of extracellular vesicles in mediating drug resistance and intercellular communication within the tumor microenvironment is emerging as a significant area of interest.
Declining or Waning
- Traditional Chemotherapy Resistance Mechanisms:
Research on traditional chemotherapy resistance mechanisms, such as those related to classic cytotoxic agents, has been less prominent in recent publications, as the focus shifts toward targeted therapies and immunotherapy. - Single-Agent Therapeutic Approaches:
There appears to be a waning interest in studies focusing solely on single-agent therapies, as the field moves towards combination therapies that address multiple resistance mechanisms simultaneously. - Basic Research without Clinical Relevance:
Papers that delve into basic research without direct clinical implications or translational potential have become less frequent, as there is a stronger emphasis on studies that can directly inform clinical practice.
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