Cellular and Molecular Bioengineering
Scope & Guideline
Innovating at the Intersection of Biology and Technology
Introduction
Aims and Scopes
- Tissue Engineering and Regenerative Medicine:
Research exploring the development and application of biomaterials and scaffolds for the regeneration of tissues and organs, including the engineering of extracellular matrices and stem cell therapies. - Cellular Mechanotransduction:
Investigations into how cells sense and respond to mechanical stimuli, which plays a crucial role in various physiological and pathological processes. - Microfluidic and Organ-on-a-Chip Technologies:
Innovative designs and applications of microfluidic systems that simulate human organ functions, facilitating drug testing and disease modeling. - Synthetic Biology and Genetic Engineering:
Studies focused on the design of novel biological parts and systems, including the use of engineered proteins and genetic circuits for therapeutic applications. - Cancer Biology and Therapeutics:
Research on the cellular and molecular mechanisms underlying cancer progression and metastasis, along with the development of targeted therapies and drug delivery systems. - Extracellular Vesicles and Cell Communication:
Exploration of the role of extracellular vesicles in intercellular communication and their potential as therapeutic agents. - Biophysical Characterization of Cells:
Utilization of biophysical techniques to characterize cellular behavior, including studies on cell motility, adhesion, and mechanical properties.
Trending and Emerging
- Artificial Intelligence and Machine Learning Applications:
The integration of AI and machine learning techniques into bioengineering research is on the rise, particularly for data analysis, predictive modeling, and enhancing educational methodologies. - Advanced Biomaterials and Hydrogel Technologies:
There is a growing focus on the development of new biomaterials and hydrogels that mimic the extracellular matrix, enhancing tissue engineering applications and regenerative medicine. - Intercellular Communication Mechanisms:
Research on the role of extracellular vesicles and other forms of cell communication is increasingly important, highlighting their potential in therapeutic applications and disease modeling. - Personalized Medicine and Precision Therapies:
An emphasis on tailoring treatments based on individual patient profiles is emerging, particularly in cancer therapies and regenerative medicine, leveraging bioengineering innovations. - Tumor Microenvironment Studies:
There is a noticeable trend towards investigating the complex interactions within tumor microenvironments, utilizing novel in vitro models to better understand cancer biology and therapeutic resistance.
Declining or Waning
- Traditional In Vitro Models:
Research utilizing standard two-dimensional cell culture systems appears to be diminishing as the field moves toward more complex, physiologically relevant three-dimensional models. - Basic Cellular Mechanisms without Therapeutic Applications:
Studies focusing solely on fundamental cellular processes without direct applications to therapy or engineering solutions are becoming less prominent, as there is a growing emphasis on translational research. - Single-Cell Analysis Technologies:
Although still important, there seems to be a reduction in the number of publications solely dedicated to single-cell sequencing or profiling technologies, as these methods become more integrated into broader studies. - Animal Models for Drug Testing:
Research relying heavily on traditional animal models for drug testing is declining in favor of human-relevant models such as organ-on-a-chip systems.
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