Clinical Pharmacology in Drug Development
Scope & Guideline
Exploring the future of drug efficacy and safety.
Introduction
Aims and Scopes
- Pharmacokinetics and Pharmacodynamics:
Research that explores the absorption, distribution, metabolism, and excretion of drugs, alongside their biological effects, is a core focus. This includes studies on drug-drug interactions and the impact of genetic factors on drug response. - Bioequivalence Studies:
The journal frequently publishes studies assessing the bioequivalence of generic and branded drugs, which are critical for regulatory approvals and market access. - Safety and Tolerability Assessments:
A significant portion of the research is dedicated to evaluating the safety profiles of new drugs, including adverse effects and tolerability in diverse populations. - Population Pharmacokinetics:
Studies that utilize population pharmacokinetic modeling to analyze drug behavior in specific patient groups, including those with comorbidities or differing ethnic backgrounds, are highlighted to enhance personalized medicine. - Phase I Clinical Trials:
The journal emphasizes research from Phase I trials, which are essential for understanding the initial safety, tolerability, and pharmacokinetic profiles of new therapeutic agents. - Innovative Drug Development Methodologies:
The journal encourages submissions that explore new methodologies in drug development, including model-informed approaches and adaptive trial designs.
Trending and Emerging
- Personalized Medicine Approaches:
There is an increasing emphasis on studies that explore personalized medicine, particularly how individual genetic makeup influences drug response and safety, reflecting a broader trend in healthcare towards tailored therapies. - Innovations in Drug Delivery Systems:
Research focusing on novel drug delivery systems, including sustained-release formulations and targeted delivery mechanisms, has gained traction, highlighting advancements in improving drug efficacy and patient compliance. - Real-World Evidence and Post-Marketing Surveillance:
The journal is increasingly publishing studies that utilize real-world evidence to assess drug performance post-approval, emphasizing the importance of understanding drug effects in everyday clinical practice. - Complex Drug Interactions:
The complexity of drug-drug interactions, especially involving polypharmacy in older populations or patients with comorbid conditions, is becoming a more prominent area of research, reflecting the realities of modern healthcare. - Evolving Regulatory Science:
There is a growing interest in the regulatory aspects of drug development, including submissions that discuss the implications of new regulations on clinical trial designs and drug approval processes.
Declining or Waning
- Traditional Drug Formulations:
There has been a noticeable decline in studies focused solely on traditional drug formulations without considering innovative delivery systems or combinations. The shift towards more complex formulations and combination therapies is evident. - Non-Clinical Studies:
Research that primarily focuses on non-clinical or preclinical studies has decreased, as the journal emphasizes clinical data and results from human trials. - Fixed-Dose Combinations without Novel Insights:
Publications that discuss fixed-dose combinations without providing new insights into their pharmacokinetic profiles or novel therapeutic outcomes have become less frequent, as the field moves towards more innovative combinations. - Pharmacogenomics Studies:
Although pharmacogenomics remains important, the specific focus on genetic polymorphisms affecting pharmacokinetics has seen a decline, possibly due to the broader integration of such analyses into standard pharmacokinetic studies.
Similar Journals
FARMACIA
Exploring the Frontiers of Pharmacology and Toxicology.FARMACIA is a renowned academic journal published by the SOC STIINTE FARMACEUTICE ROMANIA, specializing in the field of pharmacology, toxicology, and pharmaceutics. With a rich history dating back to its initial publication years of 1945 to 1946, and ongoing contributions since 2008, the journal has established itself as a significant platform for disseminating cutting-edge research in the pharmaceutical sciences. Indexed in Scopus, it holds a commendable Q2 ranking in the Pharmacology, Toxicology and Pharmaceutics category, reflecting its importance in the field. The journal aims to foster knowledge sharing and innovation among researchers, professionals, and students alike, making it an essential resource for advancing pharmaceutical research. Although it does not currently offer Open Access, the content is accessible to a broad academic audience, ensuring valuable insights into current trends and discoveries in pharmacotherapy and drug development. For those seeking a deeper understanding of the evolving landscape of pharmaceutical sciences, FARMACIA provides a critical lens through which to explore and engage with the latest scientific advancements.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Transforming Pharmacology Through Rigorous ResearchBritish Journal of Clinical Pharmacology, published by Wiley, is a premier peer-reviewed journal that has been at the forefront of pharmacology research since its inception in 1974. Renowned for its high academic rigor, it stands out with an impressive impact factor that places it in the Q1 quartile within both the general pharmacology and medical pharmacology categories. With a Scopus ranking reflecting its esteemed status—ranked #68 out of 272 in medical pharmacology and #109 out of 313 in pharmacology, toxicology, and pharmaceutics—the journal serves as a critical resource for researchers, clinicians, and students who are keen to explore innovations and advancements in drug therapy. The journal's scope encompasses a wide array of topics, including clinical trials, drug safety, and pharmacokinetics, making it an essential platform for disseminating cutting-edge pharmacological findings. Although it does not offer open access, the stringent selection of articles ensures that only the highest-quality research is published, further contributing to the ongoing discourse in clinical pharmacology.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Elevating Research through Expert AnalysisExpert Opinion on Investigational Drugs, published by Taylor & Francis Ltd, is a premier journal dedicated to the dissemination of high-quality, peer-reviewed research in the fields of pharmacology and medicine. As an integral part of the scientific community since its inception in 1994, this journal has established itself as a leading source of insightful analysis and expert commentary on emerging drug therapies, providing invaluable resources for researchers, clinicians, and healthcare professionals. With an impressive impact factor and ranking in the top quartile across multiple pharmacological categories, it remains a vital platform for discussing innovative drug developments and their clinical applications. Though it operates on a subscription basis, Expert Opinion on Investigational Drugs is crucial for anyone involved in pharmacological research and the drug development process, positioning itself at the forefront of medical advancements and offering critical insights into the rapid evolution of investigational therapies.
DRUG METABOLISM REVIEWS
Unraveling the complexities of drug interactions.Drug Metabolism Reviews is a premier journal dedicated to the dissemination of scientific research and reviews in the field of pharmacology, toxicology, and pharmaceutics, published by Taylor & Francis Ltd. With its inception dating back to 1972, this journal has consistently provided an authoritative platform for scholars and professionals from diverse disciplines to explore the intricate mechanisms of drug metabolism and their implications for therapeutic applications. The journal enjoys commendable rankings, placing in the Q2 quartile for Pharmacology (medical) and the Q1 quartile in the miscellaneous subfield, signaling its significant impact within the community. Notably, it is recognized within the top 96th percentile in General Pharmacology, Toxicology and Pharmaceutics, affirming its esteemed position among academic publications. Although it operates under a subscription model, Drug Metabolism Reviews remains an essential resource for researchers, professionals, and students seeking to deepen their understanding of drug interactions, safety, and efficacy. The insights shared within its pages contribute vital knowledge to the global discourse on drug development and personalized medicine.
DRUG METABOLISM AND DISPOSITION
Shaping the Future of Pharmaceutical ResearchDrug Metabolism and Disposition is a premier journal published by the American Society for Pharmacology and Experimental Therapeutics, focusing on crucial advancements in the fields of pharmaceutical sciences and pharmacology. Since its inception in 1973, this esteemed journal has established itself as a leading platform for innovative research, earning a prestigious Q1 rating in both Pharmaceutical Science and Pharmacology categories as of 2023. With an impressive Scopus ranking of #52 out of 183 in Pharmaceutical Science and #105 out of 313 in Pharmacology, it occupies a vital place in an increasingly competitive academic landscape. Researchers, professionals, and students alike benefit from its rigorous peer-reviewed articles that delve into drug metabolism processes and their physiological implications, making it an indispensable resource for anyone aiming to advance their understanding of drug disposition and efficacy. This crucial journal contributes significantly to the ongoing dialogue in pharmacology and toxicology, providing insights that help shape future therapeutic strategies and regulatory policies.
Expert Opinion on Drug Metabolism & Toxicology
Connecting Experts in Pharmacology and ToxicologyExpert Opinion on Drug Metabolism & Toxicology, published by Taylor & Francis Ltd, is a leading journal in the fields of pharmacology and toxicology, with a distinguished reputation gleaned from its Q1 rankings in both disciplines as of 2023. With an ISSN of 1742-5255 and an E-ISSN of 1744-7607, this journal aims to foster innovative discussions and critical insights into the metabolism and toxicological assessment of drugs, appealing to a wide audience of researchers, professionals, and students. The journal's commitment to maintaining high academic standards is reflected in its placement within the top quartiles of the Scopus rankings—ranked 17th in Toxicology and 73rd in Pharmacology—demonstrating its significant impact and relevance in advancing knowledge within the drug development sector. Published since 2005 and converging into 2024, it provides a platform for timely dissemination of expert opinions, systematic reviews, and original research, reinforcing its vital role in shaping the future of pharmacological sciences in an ever-evolving landscape.
AAPS Journal
Shaping the Future of Pharmaceutical Research and Applications.AAPS Journal, published by Springer in the United States, is a leading peer-reviewed journal dedicated to the advancement of research in the field of Pharmaceutical Sciences. With an impressive Q1 rank in its category and a position within the 81st percentile of Scopus rankings, it serves as a vital resource for researchers and professionals seeking to disseminate impactful findings and innovative methodologies. The journal publishes high-quality original research, review articles, and technical reports aimed at addressing the multifaceted challenges in pharmacology, toxicology, and pharmaceutics. Operating under an Open Access model, AAPS Journal ensures broad dissemination of knowledge, contributing to the enhanced visibility and accessibility of research outputs. With a publication window spanning from 1999 to 2024, it continues to shape the future of pharmaceutical research and its applications. Researchers, students, and industry professionals will find a valuable repository of cutting-edge knowledge in this esteemed journal.
European Journal of Pharmacology
Fostering interdisciplinary collaboration in the realm of pharmacology.The European Journal of Pharmacology, a prestigious publication by Elsevier, serves as a vital resource in the field of pharmacology, offering rich insights into drug development and therapeutic applications. Since its inception in 1967, this journal has evolved to encompass groundbreaking research, including pharmacokinetics, toxicology, and innovative pharmacological methodologies, making it an essential platform for researchers and professionals alike. With an impressive impact factor that places it in the Q1 category of pharmacological journals and a Scopus ranking of #49 out of 313, the journal is recognized in the 84th percentile within its category, solidifying its significance in the academic community. Although the journal is not open access, it continues to attract contributions from leading scientists worldwide, ensuring that cutting-edge findings are disseminated effectively. The European Journal of Pharmacology not only highlights advancements in drug discovery and clinical applications but also promotes interdisciplinary collaboration, ultimately contributing to the progress of healthcare globally.
ADMET and DMPK
Pioneering research at the intersection of absorption and metabolism.ADMET and DMPK is a premier open-access journal published by IAPC PUBLISHING since 2013, focusing on the rapidly evolving fields of ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) and DMPK (Drug Metabolism and Pharmacokinetics). Catering to researchers, professionals, and students in the realms of pharmacology, toxicology, and medicinal chemistry, this journal plays a crucial role in fostering innovation and collaboration within the interdisciplinary landscape of drug development. With an impressive Q1 ranking in Pharmacology, Toxicology and Pharmaceutics and ranking in the top percentiles across various categories such as Chemistry and Health, ADMET and DMPK provides a reputable platform for high-quality publications. Its global reach, complemented by its open-access model, ensures that valuable research is accessible to a wide audience. As we converge towards 2024, this journal remains dedicated to advancing knowledge and practices that shape the future of drug discovery and safety, making it an essential resource in the scientific community.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Delivering High-Impact Research for Healthcare ProfessionalsBASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, published by WILEY, serves as a vital resource in the fields of medicine, pharmacology, and toxicology. With an ISSN of 1742-7835 and E-ISSN 1742-7843, this journal has established a robust reputation, reflected in its Q2 classification across its categories in 2023. It aims to disseminate high-quality research and reviews that bridge the gap between basic scientific findings and clinical applications. Operating from the United States with an address at 111 RIVER ST, HOBOKEN 07030-5774, NJ, this journal focuses on the intersection of drug action and toxicity, making it an essential platform for researchers, healthcare professionals, and students. With a converged publication timeline from 2004 to 2024, BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY continues to make significant contributions to understanding pharmacological treatments and toxicological challenges. Open access options are available to broaden the reach and impact of its published work.