DIFFERENTIATION

Scope & Guideline

Shaping the Future of Developmental Research

Introduction

Welcome to the DIFFERENTIATION information hub, where our guidelines provide a wealth of knowledge about the journal’s focus and academic contributions. This page includes an extensive look at the aims and scope of DIFFERENTIATION, highlighting trending and emerging areas of study. We also examine declining topics to offer insight into academic interest shifts. Our curated list of highly cited topics and recent publications is part of our effort to guide scholars, using these guidelines to stay ahead in their research endeavors.
LanguageEnglish
ISSN0301-4681
PublisherELSEVIER SCI LTD
Support Open AccessNo
CountryNetherlands
TypeJournal
Convergefrom 1973 to 2024
AbbreviationDIFFERENTIATION / Differentiation
Frequency6 issues/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
Address125 London Wall, London EC2Y 5AS, ENGLAND

Aims and Scopes

The journal 'Differentiation' focuses on the intricate processes of cellular differentiation and development, exploring the molecular and genetic underpinnings that guide these phenomena. It serves as a platform for researchers to disseminate findings related to various aspects of differentiation across multiple biological systems.
  1. Cellular Differentiation Mechanisms:
    The journal emphasizes the molecular signaling pathways and genetic factors that drive cellular differentiation, including studies on growth factors, signaling molecules, and transcription factors.
  2. Developmental Biology:
    A core area of focus is developmental biology, examining the processes that occur during embryogenesis and organogenesis, with particular attention to how cells and tissues develop and differentiate.
  3. Stem Cell Research:
    The journal publishes significant research on stem cells, including their differentiation potential, mechanisms of pluripotency, and applications in regenerative medicine.
  4. Model Organisms:
    Research utilizing model organisms such as zebrafish, mouse, and human pluripotent stem cells is a consistent theme, providing insights into differentiation processes that can be extrapolated to human biology.
  5. Epigenetics and Differentiation:
    The role of epigenetic modifications in regulating gene expression during differentiation is a focal point, with studies exploring how these changes influence cellular fate.
  6. Pathological Implications of Differentiation:
    The journal also addresses the pathological aspects of differentiation, including how aberrations in normal differentiation processes can lead to diseases such as cancer or developmental disorders.
Recent publications in 'Differentiation' indicate a clear trend towards exploring new themes and methodologies that reflect the current advancements in the field of developmental biology and differentiation.
  1. Fibroblast Growth Factors (FGFs):
    There is a growing emphasis on fibroblast growth factors, with numerous recent papers dedicated to understanding their roles in development, signaling pathways, and therapeutic potentials.
  2. Stem Cell Differentiation Pathways:
    Research increasingly focuses on specific pathways that regulate stem cell differentiation, including the influence of non-coding RNAs and epigenetic factors, highlighting their critical roles in lineage specification.
  3. Organoid and 3D Culture Systems:
    Emerging studies are utilizing organoid technology and 3D culture systems to better mimic in vivo conditions, allowing for more accurate modeling of differentiation processes and disease mechanisms.
  4. Mechanobiology in Differentiation:
    The intersection of mechanical forces and cellular differentiation is gaining traction, with studies exploring how biomechanical cues influence cell fate decisions.
  5. Systems Biology Approaches:
    A trend towards systems biology approaches is evident, where researchers are employing network analysis and transcriptomic data to uncover complex interactions involved in differentiation.

Declining or Waning

While 'Differentiation' has maintained a strong focus on various aspects of development and differentiation, certain themes have seen a decline in prominence over recent years. These waning scopes reflect shifting interests and advancements in the field.
  1. Hormonal Regulation of Differentiation:
    Although hormonal influences on differentiation were previously a significant focus, recent publications indicate a decrease in studies exploring the effects of hormones, particularly estrogens, on developmental processes.
  2. Gene Manipulation Techniques:
    There has been a noticeable reduction in the exploration of traditional gene manipulation techniques in favor of more advanced methodologies such as CRISPR and other genome editing technologies.
  3. In Vitro Models of Differentiation:
    Research utilizing standard in vitro models for studying differentiation has decreased, as there is a shift towards more complex and physiologically relevant systems, such as organoids and 3D cultures.
  4. Comparative Developmental Studies:
    The comparative analysis of developmental processes across different species has become less frequent, as the focus shifts more towards human-specific studies and translational research.

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