Fluids and Barriers of the CNS

Scope & Guideline

Bridging Knowledge Gaps in CNS Research and Innovation

Introduction

Explore the comprehensive scope of Fluids and Barriers of the CNS through our detailed guidelines, including its aims and scope. Stay updated with trending and emerging topics, and delve into declining areas to understand shifts in academic interest. Our guidelines also showcase highly cited topics, featuring influential research making a significant impact. Additionally, discover the latest published papers and those with high citation counts, offering a snapshot of current scholarly conversations. Use these guidelines to explore Fluids and Barriers of the CNS in depth and align your research initiatives with current academic trends.
LanguageEnglish
ISSN2045-8118
PublisherBMC
Support Open AccessYes
CountryUnited Kingdom
TypeJournal
Convergefrom 2011 to 2024
AbbreviationFLUIDS BARRIERS CNS / Fluids Barriers CNS
Frequency1 issue/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
AddressCAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND

Aims and Scopes

The journal 'Fluids and Barriers of the CNS' primarily focuses on the study of cerebrospinal fluid (CSF) dynamics, blood-brain barrier (BBB) integrity, and their implications in central nervous system (CNS) disorders. It encompasses a multidisciplinary approach, integrating molecular biology, neuroimaging, and clinical research to advance understanding and treatment of CNS diseases.
  1. Cerebrospinal Fluid Dynamics:
    Research on the production, flow, and absorption of cerebrospinal fluid, including its role in maintaining intracranial pressure and its implications for conditions such as hydrocephalus.
  2. Blood-Brain Barrier Integrity:
    Investigating the mechanisms that regulate the permeability and function of the blood-brain barrier, particularly in the context of neurological diseases and therapeutic delivery.
  3. Neuroinflammation and Immune Response:
    Exploring the role of immune responses and neuroinflammation in CNS disorders, including the impact of various cytokines and immune cells on cerebrospinal fluid dynamics and blood-brain barrier function.
  4. Modeling and Imaging Techniques:
    Utilizing advanced imaging technologies and modeling techniques to study cerebrospinal fluid dynamics and blood-brain barrier properties, contributing to a better understanding of CNS pathophysiology.
  5. Therapeutic Approaches:
    Focusing on innovative therapeutic strategies aimed at enhancing drug delivery to the CNS, including the use of nanoparticles, ultrasound, and other methods to modulate blood-brain barrier permeability.
  6. Aging and Developmental Biology:
    Examining how aging affects cerebrospinal fluid dynamics and blood-brain barrier integrity, as well as the implications for neurodegenerative diseases.
The journal has witnessed a significant evolution in its thematic focus, with several emerging trends that reflect current scientific interests and advancements in the field. These trends highlight the integration of new technologies and methodologies to enhance understanding of CNS pathophysiology.
  1. Advanced Imaging Techniques:
    There is a growing emphasis on employing advanced imaging modalities, such as 4D flow MRI and high-resolution microimaging, to study cerebrospinal fluid dynamics and blood-brain barrier integrity in real time.
  2. In Vitro Models of the Blood-Brain Barrier:
    Research is increasingly utilizing in vitro models, including iPSC-derived and organoid systems, to better mimic the blood-brain barrier and study drug delivery mechanisms in a controlled environment.
  3. Role of the Choroid Plexus:
    Emerging studies focus on the physiological and pathological roles of the choroid plexus in cerebrospinal fluid production and its involvement in neurodegenerative diseases.
  4. Neuroinflammation and its Impact on CNS Function:
    There is a trend towards exploring the relationship between neuroinflammation, cerebrospinal fluid dynamics, and neurodegenerative disorders, emphasizing the role of cytokines and immune cells.
  5. Therapeutic Innovations for CNS Delivery:
    The journal is increasingly publishing studies on innovative therapeutic strategies, including ultrasound-mediated drug delivery and nanotechnology, aimed at enhancing therapeutic efficacy in the CNS.
  6. Aging and Neurodegeneration:
    Research on the effects of aging on cerebrospinal fluid dynamics and blood-brain barrier function is gaining traction, reflecting the increasing relevance of these factors in neurodegenerative diseases.

Declining or Waning

While 'Fluids and Barriers of the CNS' continues to expand its focus on various aspects of cerebrospinal fluid and blood-brain barrier research, some themes appear to be less prominent in recent publications. These areas may reflect shifts in research priorities or advances in understanding that have led to less frequent exploration.
  1. Basic Descriptive Studies of CNS Anatomy:
    There has been a noticeable decline in purely descriptive studies focusing on the anatomy of the CNS without a direct link to functional implications or clinical relevance.
  2. Non-Integrated Approaches to CNS Disorders:
    Research that does not integrate findings from multiple disciplines, such as molecular biology, clinical studies, and imaging, appears to be waning, as the journal emphasizes more holistic and interdisciplinary methods.
  3. Traditional Drug Delivery Methods:
    Interest in conventional methods of drug delivery to the CNS is decreasing, with a shift towards more innovative approaches that enhance drug efficacy and targeting.
  4. Static Models of Fluid Dynamics:
    There is a decrease in studies using static models for cerebrospinal fluid dynamics, as more researchers adopt dynamic, in vivo, or clinically relevant models.

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