Tissue Barriers
Scope & Guideline
Illuminating the Pathways of Health and Disease
Introduction
Aims and Scopes
- Investigation of Barrier Functionality:
The journal emphasizes research on the integrity and functionality of various biological barriers, including the blood-brain barrier, gut-vascular barrier, and epithelial barriers, exploring their physiological roles and responses to external stimuli. - Pathogenesis of Barrier Dysfunction:
A significant focus is placed on understanding the mechanisms underlying barrier dysfunction in various diseases, such as inflammatory bowel disease, cancer, and infectious diseases, providing insights into disease progression and potential therapeutic targets. - Therapeutic Strategies and Innovations:
The journal encourages research on novel therapeutic approaches aimed at restoring barrier integrity or enhancing barrier function, including the use of nutraceuticals, stem cell therapy, and engineered biomaterials. - Molecular and Cellular Mechanisms:
Research published in 'Tissue Barriers' often delves into the molecular and cellular basis of barrier formation and maintenance, including studies on tight junction proteins, signaling pathways, and cellular interactions that influence barrier properties. - Modeling and Technology Development:
The journal features advancements in experimental models and technologies, such as organ-on-a-chip systems and in vitro models, to better understand barrier dynamics and to test therapeutic interventions.
Trending and Emerging
- Microbiota and Barrier Interaction:
There is a notable increase in research exploring the relationship between microbiota and barrier function, particularly in gastrointestinal diseases. Understanding how microbiota influence barrier integrity is becoming a critical area of investigation. - Inflammation and Barrier Dysfunction:
Recent publications highlight the role of inflammatory processes in disrupting barrier integrity across various tissues. This trend underscores the importance of inflammation as a common theme in many diseases affecting barrier function. - Nutraceuticals and Natural Compounds:
The exploration of nutraceuticals and natural compounds as potential modulators of barrier function has gained momentum. This trend reflects a growing interest in alternative therapeutic strategies that leverage dietary components for health benefits. - Advanced Modeling Techniques:
There is a surge in the use of advanced modeling techniques, such as organ-on-a-chip systems, to study barrier function in vitro. These innovative approaches allow for more precise investigations into barrier dynamics and responses to various stimuli. - Cancer and Barrier Interactions:
Research focusing on the interactions between cancer cells and barrier tissues is on the rise. This includes studies on how tumors manipulate barrier integrity to facilitate metastasis and evade immune responses.
Declining or Waning
- Basic Physiology of Barriers:
There appears to be a waning interest in purely physiological studies of barrier function, as recent publications increasingly emphasize pathological contexts or therapeutic interventions rather than foundational physiological research. - Historical Perspectives on Barrier Research:
Papers focusing on historical reviews or basic overviews of barrier structures and functions have become less common, indicating a move towards more applied research that addresses current challenges in barrier dysfunction. - Single-Barrier Studies:
Research that concentrates solely on individual barriers, without considering their interactions with other systems or the broader context of barrier networks, is becoming less prevalent, suggesting a shift towards integrative approaches.
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