Immunity & Ageing
Scope & Guideline
Unveiling the Secrets of Immune Function in Aging
Introduction
Aims and Scopes
- Immunosenescence and Inflammaging:
Research on how aging affects the immune system, leading to reduced immune function (immunosenescence) and chronic low-level inflammation (inflammaging), which contribute to age-related diseases. - Age-Related Disease Mechanisms:
Exploration of the immune mechanisms involved in age-related diseases such as Alzheimer's, cardiovascular diseases, and cancer, focusing on how aging modifies disease progression and treatment efficacy. - Therapeutic Strategies for Aging:
Development of interventions aimed at improving immune responses in older adults, including vaccine efficacy, immunotherapies, and lifestyle modifications to enhance health span. - Microbiome and Aging:
Investigating the role of gut microbiota in modulating immune responses and their impact on aging and age-related diseases. - Sex Differences in Immunity and Aging:
Studies focusing on how biological sex influences immune aging and response to diseases, highlighting the need for sex-specific approaches in research and treatment.
Trending and Emerging
- Impact of COVID-19 on Aging:
A significant increase in research addressing the effects of COVID-19 on older adults, particularly focusing on immune responses, vaccination efficacy, and long-term health implications. - Personalized Immunotherapy Approaches:
Emerging interest in personalized medicine and immunotherapy for older adults, including the use of biomarkers to tailor treatments based on individual immune profiles and responses. - Role of the Gut Microbiome:
Growing research on the gut microbiome's influence on immune function and aging, emphasizing the need for interventions that modulate microbiota to enhance health outcomes in older populations. - Neuroinflammation and Cognitive Decline:
Increased focus on the relationship between neuroinflammation and cognitive decline in aging, particularly in the context of neurodegenerative diseases like Alzheimer's. - Sarcopenia and Immunity:
Emerging studies linking sarcopenia with immune dysfunction in older adults, exploring how muscle health impacts immune responses and overall aging.
Declining or Waning
- Traditional Vaccine Responses:
Research on conventional vaccine responses in older adults has decreased as newer studies emphasize the role of hybrid immunity and personalized vaccine strategies tailored for the elderly. - Basic Mechanisms of Aging:
The exploration of fundamental biological mechanisms of aging, such as telomere shortening and oxidative stress, appears to be waning in favor of more applied research focused on immunological outcomes and therapeutic applications. - Non-Inflammatory Aging Mechanisms:
There has been a noticeable reduction in studies focused solely on aging without the context of immune response, as the field increasingly prioritizes the intersection of immunity and aging.
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