IMMUNOLOGY
Scope & Guideline
Connecting Basic Science with Clinical Applications
Introduction
Aims and Scopes
- Immune Response Mechanisms:
Research on the cellular and molecular mechanisms underlying immune responses, including the roles of T cells, B cells, macrophages, and innate lymphoid cells. - Immunotherapy Innovations:
Studies focused on developing and refining immunotherapeutic approaches, such as CAR-T cell therapy, monoclonal antibodies, and vaccines, especially in cancer and infectious diseases. - Disease Models and Mechanisms:
Investigations utilizing various disease models to elucidate immunopathological processes, including autoimmunity, allergies, and infectious diseases. - Microbiota and Immune Interactions:
Exploration of the complex relationships between gut microbiota and immune system function, impacting health, disease, and therapeutic responses. - Immune System and Metabolism:
Research linking metabolic processes to immune cell function and differentiation, highlighting the influence of metabolic states on immune responses.
Trending and Emerging
- Single-Cell Omics:
An increasing number of studies utilize single-cell RNA sequencing and other omics technologies to dissect immune cell populations and their functions at unprecedented resolution. - Immunometabolism:
Emerging research highlights the interplay between metabolism and immune function, revealing how metabolic reprogramming affects immune responses and potential therapeutic targets. - Therapeutic Targeting of Immune Checkpoints:
A surge in studies targeting immune checkpoints, particularly in cancer immunotherapy, showcases the ongoing exploration of novel treatment strategies. - Microbiome and Immune Regulation:
Research on the role of the microbiome in modulating immune responses is gaining traction, emphasizing its significance in health and disease. - Nanomedicine and Immunology:
The integration of nanotechnology in immunotherapy and drug delivery systems is becoming a prominent theme, reflecting innovations in treatment methodologies.
Declining or Waning
- Traditional Vaccine Development:
There has been a noticeable reduction in publications focused on traditional vaccine development, possibly due to a shift towards mRNA and novel vaccine technologies. - Basic Immunological Pathways:
Research on well-established immune pathways, such as basic cytokine signaling, is appearing less frequently as the field progresses toward more complex interactions and systems biology approaches. - Animal Models in Immunology:
The reliance on animal models for studying immune responses is waning in favor of humanized models and in vitro systems, as researchers seek more translational relevance.
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