INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
Scope & Guideline
Unraveling Complexities in Pathology and Beyond
Introduction
Aims and Scopes
- Pathological Mechanisms in Disease:
Research aimed at uncovering the fundamental mechanisms underlying various diseases, particularly focusing on how the extracellular matrix (ECM) contributes to disease pathology. - Innovative Experimental Techniques:
Utilization of advanced experimental methodologies, including in vivo models, gene therapy, and proteomics, to investigate disease mechanisms and potential therapeutic targets. - Matrix Biology and Tissue Engineering:
Studies emphasizing the role of the extracellular matrix in tissue repair, regeneration, and the development of innovative scaffolds for regenerative medicine. - Molecular and Cellular Interactions:
Exploration of the molecular pathways and cellular interactions that drive pathology, including the involvement of microRNAs, signaling pathways, and immune responses. - Translational Research:
Research that bridges the gap between basic science and clinical applications, particularly in understanding the implications of findings for therapeutic interventions in human diseases.
Trending and Emerging
- Extracellular Matrix (ECM) Dynamics:
A growing focus on the role of ECM in various diseases, particularly how ECM remodeling affects cellular behavior and disease progression, highlighting its importance in both pathology and therapy. - MicroRNA and Gene Regulation:
Increased publications on the role of microRNAs in regulating gene expression and their implications in various diseases, indicating a trend towards understanding post-transcriptional regulation in pathology. - Immune Response and Inflammation:
Emerging research on the role of the immune system and inflammatory processes in disease pathology, reflecting a broader understanding of how immune mechanisms influence disease outcomes. - Regenerative Medicine and Tissue Engineering:
A surge in studies related to regenerative medicine, particularly focusing on using stem cells and bioengineered tissues to repair or replace damaged organs and tissues, showcasing a significant trend in translational research. - Novel Therapeutic Strategies:
An increasing interest in innovative therapeutic approaches, including gene therapy and targeted treatments, which are becoming central to research as the field looks for new solutions to complex diseases.
Declining or Waning
- Traditional Histopathology Techniques:
There is a noticeable reduction in studies relying solely on traditional histopathological methods, as the field increasingly embraces molecular and genetic approaches to understand diseases. - Animal Models of Disease:
Although animal models are still relevant, there is a trend towards using more sophisticated in vitro systems, including organoids and 3D cultures, which may indicate a waning interest in basic animal studies for certain pathologies. - Basic Biochemical Analysis:
Papers focusing on basic biochemical analyses without integrating broader biological contexts or advanced technologies are becoming less prevalent, as the field moves towards more integrative and systems biology approaches.
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