Cell Death & Disease

Scope & Guideline

Leading the charge in transformative biomedical discoveries.

Introduction

Welcome to the Cell Death & Disease information hub, where our guidelines provide a wealth of knowledge about the journal’s focus and academic contributions. This page includes an extensive look at the aims and scope of Cell Death & Disease, highlighting trending and emerging areas of study. We also examine declining topics to offer insight into academic interest shifts. Our curated list of highly cited topics and recent publications is part of our effort to guide scholars, using these guidelines to stay ahead in their research endeavors.
LanguageEnglish
ISSN2041-4889
PublisherSPRINGERNATURE
Support Open AccessYes
CountryUnited Kingdom
TypeJournal
Convergefrom 2010 to 2024
AbbreviationCELL DEATH DIS / Cell Death Dis.
Frequency1 issue/year
Time To First Decision-
Time To Acceptance-
Acceptance Rate-
Home Page-
AddressCAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND

Aims and Scopes

Cell Death & Disease focuses on the mechanisms of cell death and their implications in various diseases, particularly cancer. The journal emphasizes the interplay between cell death pathways and disease progression, providing insights into potential therapeutic strategies.
  1. Cell Death Mechanisms:
    The journal covers various forms of cell death including apoptosis, necroptosis, pyroptosis, and autophagy, exploring their molecular underpinnings and roles in disease processes.
  2. Cancer Research:
    A significant portion of the articles discusses the role of cell death in cancer biology, including mechanisms of resistance to therapies, tumor microenvironment interactions, and cancer stem cell dynamics.
  3. Therapeutic Applications:
    The journal publishes research on novel therapeutic approaches targeting cell death pathways, with implications for treating cancers and other diseases.
  4. Molecular and Cellular Biology:
    Research on the molecular signaling pathways that regulate cell death and survival, including studies on specific proteins, RNAs, and metabolic pathways, is a consistent focus.
  5. Immunology and Inflammation:
    The intersection of cell death mechanisms with immune responses and inflammation, particularly in the context of chronic diseases and cancer, is a key area of exploration.
The journal has identified several emerging themes in the research landscape, reflecting current scientific interests and advancements in understanding cell death and its implications in various diseases.
  1. Ferroptosis Research:
    Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, has gained significant attention, with numerous studies exploring its role in cancer and potential as a therapeutic target.
  2. Exosomal Communication:
    Research on the role of exosomes in mediating cell death and influencing the tumor microenvironment is on the rise, highlighting their importance in cancer progression and immune modulation.
  3. Metabolic Reprogramming:
    The interplay between cellular metabolism and cell death pathways is emerging as a critical area of study, with implications for understanding cancer metabolism and resistance to therapies.
  4. Immune Evasion Mechanisms:
    Studies focusing on how cancer cells evade immune detection through manipulation of cell death pathways and the immune microenvironment are increasingly prominent.
  5. RNA Modifications:
    The role of RNA modifications, particularly N6-methyladenosine (m6A), in regulating cell death and tumorigenesis is an emerging trend, indicating a shift toward understanding post-transcriptional regulation in cancer.

Declining or Waning

While Cell Death & Disease maintains a robust focus on cell death mechanisms, certain areas of research have seen decreased prominence in recent publications, indicating a potential shift in research priorities.
  1. Basic Cell Biology:
    Research that focuses solely on fundamental aspects of cell biology without connecting to disease mechanisms appears to be declining, as the journal increasingly emphasizes translational and therapeutic implications.
  2. Non-Cancer Related Cell Death Studies:
    There is a noticeable reduction in publications specifically addressing cell death mechanisms outside of cancer, such as those related to metabolic diseases or neurodegenerative conditions, suggesting a more cancer-centric focus.
  3. Traditional Apoptosis Studies:
    While apoptosis remains a critical topic, there seems to be a waning interest in classical studies of apoptosis mechanisms in favor of exploring more complex interactions involving necroptosis and other forms of regulated cell death.

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