JOURNAL OF INVESTIGATIVE DERMATOLOGY
Scope & Guideline
Advancing the Science of Skin Health
Introduction
Aims and Scopes
- Molecular and Cellular Mechanisms in Skin Biology:
Research focusing on the molecular and cellular underpinnings of skin function, including keratinocyte biology, immune responses, and the role of various cell types in skin health and disease. - Skin Diseases and Disorders:
Studies addressing the pathophysiology, epidemiology, and treatment of various skin conditions, including psoriasis, atopic dermatitis, skin cancers, and autoimmune blistering diseases. - Therapeutic Innovations and Clinical Trials:
Exploration of new therapeutic approaches, including the efficacy and safety of biologic agents, small molecules, and novel drug delivery systems in treating dermatological conditions. - Skin Microbiome and Its Role in Dermatology:
Investigations into the skin microbiome's influence on skin health, disease, and therapeutic responses, highlighting the complex interactions between skin-resident microorganisms and host immunity. - Genetics and Genomics in Dermatology:
Research on the genetic and epigenetic factors contributing to skin diseases, including the identification of biomarkers for disease susceptibility, progression, and treatment outcomes. - Environmental and Lifestyle Factors in Skin Health:
Studies examining how environmental factors, lifestyle choices, and systemic conditions impact skin health, disease onset, and treatment efficacy.
Trending and Emerging
- Single-Cell and Spatial Transcriptomics:
There is a growing emphasis on single-cell RNA sequencing and spatial transcriptomics to dissect the cellular heterogeneity and immune microenvironments in various skin diseases, providing insights into disease mechanisms and treatment responses. - Immunotherapy and Immune Modulation:
Research on immune checkpoint inhibitors and biologics targeting specific pathways in skin diseases is rapidly expanding, focusing on their mechanisms of action and patient response variability. - Microbiome Research in Dermatology:
The role of the skin microbiome in health and disease is gaining attention, with studies exploring how microbial communities influence skin conditions and responses to treatments. - Advanced Imaging Techniques:
Innovations in imaging technologies, such as multiphoton microscopy and reflectance confocal microscopy, are increasingly being utilized to enhance diagnostic accuracy and monitor treatment outcomes in dermatology. - Genetic and Genomic Profiling:
The integration of genetic and genomic approaches to understand skin diseases is on the rise, including the identification of genetic variants associated with disease susceptibility and treatment efficacy. - Artificial Intelligence in Dermatology:
The application of AI and machine learning for diagnostics, treatment planning, and patient management is emerging as a significant trend, transforming how dermatological research and clinical practice are conducted.
Declining or Waning
- Traditional Dermatologic Therapies:
Research on conventional topical and systemic treatments has waned as newer biologics and targeted therapies gain traction, leading to a shift in focus towards innovative therapeutic approaches. - Basic Histopathology Studies:
The prevalence of purely histopathological studies without integrated molecular or genetic analysis has decreased, as the field moves towards more comprehensive approaches that combine histopathology with molecular insights. - General Dermatological Education and Training:
Research addressing basic dermatological education has seen less emphasis, reflecting a growing focus on specialized training and the integration of advanced technologies such as AI in dermatology. - Animal Models of Skin Disease:
The reliance on traditional animal models for skin disease research is declining, with an increasing emphasis on humanized models and in vitro systems that better mimic human skin conditions.
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