Molecular Cell
Scope & Guideline
Your Gateway to Cutting-Edge Biological Discoveries.
Introduction
Aims and Scopes
- Molecular Mechanisms of Gene Regulation:
The journal emphasizes studies that elucidate how gene expression is controlled at various levels, including transcriptional regulation, RNA processing, and chromatin modifications. - Cellular Stress Responses:
Research articles often explore how cells respond to various stressors, including oxidative stress, DNA damage, and nutrient deprivation, highlighting the molecular pathways involved. - Protein Dynamics and Interactions:
Molecular Cell publishes work that investigates how proteins interact, fold, and function within cellular contexts, including the roles of molecular chaperones and post-translational modifications. - CRISPR and Genome Editing Technologies:
The journal features innovative applications and developments in CRISPR technology, focusing on its mechanisms, modifications, and implications for gene editing and therapy. - Cell Fate and Developmental Biology:
Articles related to how molecular processes influence cell differentiation, lineage specification, and developmental pathways are central to the journal's scope. - Cancer Biology and Therapeutic Strategies:
Research addressing the molecular underpinnings of cancer, including oncogenes, tumor suppressors, and therapeutic targets, is a significant focus of the journal.
Trending and Emerging
- Phase Separation and Biomolecular Condensates:
Increasingly, studies are exploring the role of phase separation in cellular organization and function, particularly how biomolecular condensates influence processes like transcription and signal transduction. - Epitranscriptomics and RNA Modifications:
Research focusing on the role of RNA modifications, such as m6A methylation, in regulating gene expression and cellular responses is gaining momentum, reflecting a growing interest in the post-transcriptional landscape. - Interplay Between Metabolism and Gene Regulation:
There is a trend towards exploring how metabolic pathways intersect with gene regulatory networks, particularly in the context of cancer metabolism and cellular stress responses. - Technological Innovations in CRISPR and Genome Editing:
Advancements in CRISPR technology are leading to new applications and refinements in genome editing, which are being actively published, showcasing the journal's commitment to cutting-edge research. - Immunology and Cancer Therapeutics:
Research that connects molecular mechanisms to immune responses, particularly in the context of cancer, is increasingly prominent, reflecting the growing importance of immunotherapy in cancer treatment.
Declining or Waning
- Studies on Classical Biochemistry:
Research focused on traditional biochemical methods and pathways has seen a decrease, as more sophisticated molecular techniques and systems biology approaches gain traction. - Basic Mechanistic Studies without Broader Implications:
There is a noticeable decline in papers that focus solely on basic mechanisms without linking them to broader biological contexts or applications, particularly in disease models. - Single-Cell Analysis Techniques:
Although single-cell technologies are still relevant, there has been a shift towards integrating multi-omic approaches rather than isolated single-cell studies, leading to fewer publications focusing exclusively on single-cell methodologies.
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