BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Scope & Guideline
Exploring the Foundations of Health and Disease
Introduction
Aims and Scopes
- Molecular Mechanisms of Disease:
The journal emphasizes research elucidating the molecular and cellular mechanisms underlying various diseases, including cancer, neurodegenerative disorders, and metabolic diseases. - Translational Research:
It focuses on studies that bridge basic research and clinical applications, aiming to translate laboratory findings into potential therapeutic strategies. - Cellular and Molecular Biology Techniques:
The journal publishes articles utilizing diverse experimental approaches, including genomics, proteomics, metabolomics, and advanced imaging techniques to explore disease mechanisms. - Therapeutic Strategies:
Research on novel therapeutic interventions, including drug development, gene therapy, and immunotherapy, is a core focus, highlighting innovative approaches to combat diseases. - Interdisciplinary Research:
The journal encourages interdisciplinary studies that integrate insights from biochemistry, molecular biology, immunology, and genetics to provide a comprehensive understanding of disease processes.
Trending and Emerging
- Microbiome and Disease:
Research investigating the role of the microbiome in disease development and progression is on the rise, highlighting the complex interactions between gut health and systemic diseases. - Immunotherapy and Immune Modulation:
There is an increasing focus on immunotherapy, particularly in cancer treatment, as studies explore the mechanisms of immune evasion and strategies to enhance anti-tumor immune responses. - Metabolic Reprogramming in Disease:
Emerging studies are emphasizing the role of metabolic reprogramming in cancer and other diseases, exploring how altered metabolism contributes to disease pathogenesis and therapy resistance. - Autophagy and Cellular Homeostasis:
Research on autophagy is gaining traction, particularly its role in cellular homeostasis, immune response, and neurodegeneration, reflecting its potential as a therapeutic target. - Personalized Medicine and Genomics:
There is a growing trend towards personalized medicine, with studies focusing on genomic alterations and their implications for tailored therapeutic approaches in various diseases.
Declining or Waning
- Traditional Pharmacology:
Research focusing solely on traditional pharmacological approaches is declining, as there is a growing interest in personalized medicine and targeted therapies that consider individual genetic and molecular profiles. - Basic Biochemical Studies:
While foundational biochemical studies are essential, there is a waning emphasis on purely descriptive biochemical research without clear implications for disease mechanisms or therapeutic strategies. - Animal Models of Disease:
The reliance on conventional animal models is decreasing, with a shift towards more complex models, including organoids and humanized systems, that better mimic human disease conditions. - Static In Vitro Studies:
There is a noticeable decline in studies that do not incorporate dynamic or three-dimensional culture systems, as the scientific community increasingly recognizes the limitations of 2D cell cultures in reflecting in vivo conditions.
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