Nature Metabolism
Scope & Guideline
Connecting metabolic mechanisms to real-world health outcomes.
Introduction
Aims and Scopes
- Metabolic Regulation and Homeostasis:
Research focused on understanding how metabolic pathways are regulated and how this regulation affects overall homeostasis in organisms, including studies on insulin signaling, energy expenditure, and metabolic adaptation. - Microbiome and Metabolism:
Exploration of the interactions between gut microbiota and host metabolism, investigating how microbial metabolites influence metabolic health and diseases such as obesity and diabetes. - Cancer Metabolism:
Examination of the metabolic alterations in cancer cells, including the role of metabolic pathways in tumorigenesis, tumor progression, and responses to therapy. - Nutritional Metabolism:
Studies on how dietary components and interventions influence metabolic health, including research on the effects of specific diets, fasting, and nutrient timing on metabolism. - Cellular and Molecular Metabolism:
Investigations into the cellular mechanisms that regulate metabolic pathways, including studies on mitochondrial function, cellular senescence, and lipid metabolism. - Translational Metabolism Research:
Research aimed at translating basic metabolic science into clinical applications, including the development of innovative therapies for metabolic diseases.
Trending and Emerging
- Omics Technologies in Metabolism:
The application of multi-omics approaches, including genomics, proteomics, and metabolomics, is increasingly prominent, allowing for a comprehensive understanding of metabolic networks and their dysregulation in diseases. - Inter-organ Communication in Metabolism:
Research focusing on how different organs communicate metabolically, particularly in the context of diabetes and obesity, is gaining traction as studies explore systemic metabolic regulation. - Metabolic Role of Extracellular Vesicles:
Emerging studies are investigating the role of extracellular vesicles in metabolic signaling and intercellular communication, highlighting their potential as biomarkers and therapeutic targets. - Personalized Nutrition and Metabolism:
There is a growing emphasis on personalized nutrition strategies that consider individual genetic and metabolic profiles, aiming to optimize dietary interventions for metabolic health. - Metabolic Reprogramming in Immune Cells:
The intersection of metabolism and immunology is a rapidly growing field, with research exploring how metabolic pathways influence immune cell function and their implications for diseases like cancer and autoimmunity.
Declining or Waning
- Traditional Diet Studies:
Research focusing solely on traditional dietary impacts without considering the microbiome or genetic factors seems to be waning, as newer studies emphasize the role of gut microbiota in dietary responses. - Simple Metabolic Pathway Studies:
There has been a noticeable decline in studies that focus solely on single metabolic pathways without considering their interactions with other biological systems, reflecting a move towards more integrative approaches. - Animal Models in Isolation:
The reliance on animal models without integrating human studies or translational approaches is decreasing, as researchers emphasize the importance of human-relevant findings in metabolic research.
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