Cancer & Metabolism
Scope & Guideline
Innovating Therapeutic Strategies at the Metabolic Frontier
Introduction
Aims and Scopes
- Metabolic Pathways in Cancer:
The journal focuses on elucidating the various metabolic pathways utilized by cancer cells, including glycolysis, oxidative phosphorylation, and lipid metabolism, to understand how these processes contribute to tumor growth and survival. - Tumor Microenvironment Interactions:
Research published in the journal often explores how the tumor microenvironment, including stromal and immune cell interactions, affects cancer metabolism and influences treatment responses. - Therapeutic Targeting of Metabolism:
A significant aim of the journal is to highlight studies that investigate metabolic vulnerabilities in cancer cells, identifying potential therapeutic targets that can be exploited for cancer treatment. - Metabolomics and Biomarkers:
The journal emphasizes the role of metabolomics in identifying biomarkers for cancer diagnosis, prognosis, and treatment response, contributing to personalized medicine approaches. - Preclinical and Clinical Studies:
'Cancer & Metabolism' publishes both preclinical and clinical research, bridging the gap between laboratory findings and their application in patient care.
Trending and Emerging
- Metabolic Reprogramming and Plasticity:
Recent publications emphasize the ability of cancer cells to adapt their metabolism in response to microenvironmental changes, which is crucial for understanding treatment resistance and tumor progression. - Role of Inflammation in Cancer Metabolism:
There is a growing interest in how systemic inflammation and the immune response affect cancer metabolism, highlighting the importance of these interactions in tumor biology and treatment outcomes. - Targeting Metabolic Checkpoints:
Research focusing on metabolic checkpoint inhibitors and their potential to enhance anti-tumor immunity is gaining traction, reflecting an innovative approach to cancer therapy. - Dietary Interventions and Cancer Metabolism:
Emerging studies are examining the impact of dietary patterns on cancer metabolism, suggesting that nutritional strategies may play a role in cancer prevention and management. - Integrative Omics Approaches:
The use of integrative omics (metabolomics, proteomics, genomics) to provide a comprehensive understanding of cancer metabolism and its complexities is increasingly prominent in recent publications.
Declining or Waning
- Basic Biochemical Pathways:
There appears to be a waning focus on fundamental biochemical pathways in cancer metabolism, as the field shifts towards more complex interactions within the tumor microenvironment and systemic metabolic changes. - Single Cancer Type Studies:
Research focusing exclusively on a single type of cancer without considering broader metabolic implications or cross-cancer comparisons has declined, as there is a growing trend towards integrative approaches that encompass multiple cancer types. - Static Metabolic Profiling:
Studies that provide static metabolic profiles without dynamic assessments or functional analyses are becoming less common, as the field increasingly values real-time and functional metabolic assessments. - Traditional Cancer Treatment Modalities:
There is a noticeable decrease in research centered on traditional chemotherapy and radiation alone, with a shift towards exploring combination therapies that target metabolic pathways alongside conventional treatments.
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